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Key Documents

142824

Sigma-Aldrich

1-Methyl-1-cyclohexanecarboxylic acid

99%

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About This Item

Linear Formula:
CH3C6H10CO2H
CAS Number:
Molecular Weight:
142.20
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Assay

99%

form

solid

bp

234 °C (lit.)

mp

36-39 °C (lit.)

SMILES string

CC1(CCCCC1)C(O)=O

InChI

1S/C8H14O2/c1-8(7(9)10)5-3-2-4-6-8/h2-6H2,1H3,(H,9,10)

InChI key

REHQLKUNRPCYEW-UHFFFAOYSA-N

General description

1-Methyl-1-cyclohexanecarboxylic acid is the structural analog of valproic acid and its pharmacokinetic action has been studied in female Sprague-Dawley rats.

Application

1-Methyl-1-cyclohexanecarboxylic acid was used as internal standard during the determination of valproic acid metabolites.

Biochem/physiol Actions

1-Methyl-1-cyclohexanecarboxylic acid is an anticonvulsant drug and causes maturation of murine neuroblastoma cells in vitro.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

213.8 °F - closed cup

Flash Point(C)

101.00 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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V P Poluianov
Sudebno-meditsinskaia ekspertiza, 35(1), 31-32 (1992-01-01)
Method of extraction-atomic absorption detection of arsenic in biologic material using naphthenic acid was developed and tested. Method can be used for arsenic detection in postmortem material. It differs from the known method by its accuracy, reliability and simple use.
Effects of 1-methyl cyclohexane carboxylic acid (CCA) on cellular energetics in neuroblastoma cells.
B Croizat et al.
Biochemical and biophysical research communications, 103(3), 1044-1051 (1981-12-15)
A J Sadeque et al.
The Journal of pharmacology and experimental therapeutics, 283(2), 698-703 (1997-11-14)
Cytochrome P450-dependent desaturation of the anticonvulsant drug valproic acid (VPA) results in formation of the hepatotoxin, 4-ene-VPA. Polytherapy with other anticonvulsants which are known P450 inducers increases the flux through this bioactivation pathway. The aim of the present study was
Effects on the cytoskeleton of a new inducer of the neuroblastoma morphological differentiation.
M M Portier et al.
Biochemical and biophysical research communications, 96(4), 1610-1618 (1980-10-31)
J L Vayssiere et al.
Biochemical and biophysical research communications, 140(3), 789-796 (1986-11-14)
CCA, a potent neuroblastoma differentiation inducer, was shown by oxygraphic measurements to reduce significantly the O2 consumption of whole neuroblastoma cells as of mitochondria purified from neuroblastoma or mouse cortex. The effect of CCA on the respiration was compared to

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