- Species difference in sensitivity to the diabetogenic action of triphenyltin hydroxide.
Species difference in sensitivity to the diabetogenic action of triphenyltin hydroxide.
Experientia (1984-04-15)
H Matsui, O Wada, S Manabe, Y Ushijima, T Fujikura
PMID6714370
ABSTRACT
The sensitivity to the diabetogenic action of triphenyltin hydroxide (TPTOH) was investigated in 5 species of experimental animals. A single oral administration of TPTOH produced marked hyperglycemia and triglyceridemia in rabbits and hamsters, but no evidence of diabetes was found in mice, rats and guinea-pigs. No morphological abnormality was observed in islet tissue from TPTOH-treated hamsters.