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Sigma-Aldrich

Chloroform

Chloroform

anhydrous, ≥99%, contains 0.5-1.0% ethanol as stabilizer

Synonym(s):

Methylidyne trichloride, Trichloromethane

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About This Item

Empirical Formula (Hill Notation):
CHCl3
CAS Number:
67-66-3
Molecular Weight:
119.38
Beilstein:
1731042
MDL number:
MFCD00000826
UNSPSC Code:
12191502
PubChem Substance ID:
57648332
NACRES:
NA.21
grade:
anhydrous
Assay:
≥99%
bp:
60.5-61.5 °C (lit.)
vapor pressure:
160 mmHg ( 20 °C)
Pricing and availability is not currently available.

grade

anhydrous

Quality Level

100

vapor density

4.1 (vs air)

vapor pressure

160 mmHg ( 20 °C)

Assay

≥99%

form

liquid

contains

0.5-1.0% ethanol as stabilizer

packaging

Sure/Seal™ of 1, 2 L
Sure/Seal™ of 100, 12x100 mL

impurities

<0.001% water
<0.005% water (100 mL pkg)

evapn. residue

<0.0003%

color

colorless

refractive index

n20/D 1.445 (lit.)

bp

60.5-61.5 °C (lit.)

mp

−63 °C (lit.)

density

1.48 g/mL at 25 °C
1.492 g/mL at 25 °C (lit.)

SMILES string

ClC(Cl)Cl

InChI

1S/CHCl3/c2-1(3)4/h1H

InChI key

HEDRZPFGACZZDS-UHFFFAOYSA-N

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General description

Chloroform is a volatile chlorinated organic solvent whose vapors have a narcotic effect.[1] Due to its light sensitivity, it may undergo degradation with time. This can be suppressed by adding ethanol as a stabilizer. The addition will increase the polarity of the solvent and potentially impact certain applications.[2]

Application

Chloroform has been used as a solvent for dissolving lipids and also as a cleansing agent.[2] It may also be used in solvent extraction process[3] and also for recrystallization.[4]

Legal Information

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

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Product No.
Description
Pricing

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

Target Organs

Central nervous system, Liver,Kidney

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

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Certificates of Analysis (COA)

Lot/Batch Number
SHBS2767
SHBR8388
SHBR6747
STBL0075
STBL0073

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Electrogenerated chemiluminescent emission from an organized (LB) monolayer of a tris (2,2'-bipyridine) ruthenium (2+)-based surfactant on semiconductor and metal electrodes
Zhang X and Bard AJ
The Journal of Physical Chemistry, 92(20), 5566-5569 (1988)
Eagleson M
Concise Encyclopedia Chemistry, 216-216 (1994)
Analytical chemistry in a drop. Solvent extraction in a microdrop
Liu H and Dasgupta PK
Analytical Chemistry, 68(11), 1817-1821 (1996)
Mariya M Kucherenko et al.
Journal of visualized experiments : JoVE, (46)(46), doi:10-doi:10 (2011-01-06)
The molecular characterization of muscular dystrophies and myopathies in humans has revealed the complexity of muscle disease and genetic analysis of muscle specification, formation and function in model systems has provided valuable insight into muscle physiology. Therefore, identifying and characterizing
High activity and regenerability of a palladium-gold catalyst for chloroform degradation.
Velazquez JC, et al.
Journal of Chemical Technology and Biotechnology (2015)
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Solvent Miscibility Table

Substances are said to be miscible in one another if they dissolve to form a uniform solution. Bookmark or download our miscibility table for common lab solvents.

Solvent Miscibility Table

Substances are said to be miscible in one another if they dissolve to form a uniform solution. Bookmark or download our miscibility table for common lab solvents.

Solvent Miscibility Table

Substances are said to be miscible in one another if they dissolve to form a uniform solution. Bookmark or download our miscibility table for common lab solvents.

Solvent Miscibility Table

Substances are said to be miscible in one another if they dissolve to form a uniform solution. Bookmark or download our miscibility table for common lab solvents.

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Questions

1–2 of 2 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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