MABS36
Anti-ODC1 Antibody, clone CPTC-ODC1-2
clone CPTC-ODC1-2, from mouse
Synonym(s):
ornithine decarboxylase 1, ornithine decarboxylase
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
CPTC-ODC1-2, monoclonal
species reactivity
human
technique(s)
western blot: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... ODC1(4953)
General description
Ornithine decarboxylase (ODC1) is the first enzyme in polyamine synthesis and is mandatory for normal growth and is increased in many types of cancers. ODC1 has been shown to suppress the fmc1 deletion in yeast and restores healthy respiratory growth. ODC1 may play a role in promoting DNA synthesis in hepatocytes.
Immunogen
Full length of recombinant protein corresponding to human ODC1.
Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program.
Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program.
Application
Research Category
Signaling
Signaling
This Anti-ODC1 Antibody, clone CPTC-ODC1-2 is validated for use in WB for the detection of ODC1.
Quality
Evaluated by Western Blot in MCF-7 cell lysate.
Western Blot Analysis: 10 µg/mL of this antibody detected ODC1 on 10 µg of MCF-7 cell lysate.
Western Blot Analysis: 10 µg/mL of this antibody detected ODC1 on 10 µg of MCF-7 cell lysate.
Target description
~51 kDa observed. A band at ~100 kDa may be observed in some lysates and may be the homodimer of this protein.
Physical form
Format: Purified
Protein G
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
MCF-7 cell lysate
MCF-7 cell lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Renee C Geck et al.
The Journal of biological chemistry, 295(19), 6263-6277 (2020-03-07)
Treatment of patients with triple-negative breast cancer (TNBC) is limited by a lack of effective molecular therapies targeting this disease. Recent studies have identified metabolic alterations in cancer cells that can be targeted to improve responses to standard-of-care chemotherapy regimens.
Guillaume N Fiches et al.
PLoS pathogens, 18(4), e1010503-e1010503 (2022-04-30)
Polyamines are critical metabolites involved in various cellular processes and often dysregulated in cancers. Kaposi's sarcoma-associated Herpesvirus (KSHV), a defined human oncogenic virus, leads to profound alterations of host metabolic landscape to favor development of KSHV-associated malignancies. In our studies
Milind D Chalishazar et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 25(16), 5107-5121 (2019-06-06)
Small-cell lung cancer (SCLC) has been treated clinically as a homogeneous disease, but recent discoveries suggest that SCLC is heterogeneous. Whether metabolic differences exist among SCLC subtypes is largely unexplored. In this study, we aimed to determine whether metabolic vulnerabilities
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