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Key Documents

810122C

Avanti

14:0-06:0 NBD PC

Avanti Research™ - A Croda Brand 810122C

Synonym(s):

1-myristoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C34H58N5O11P
CAS Number:
148533-26-0
Molecular Weight:
743.83
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (810122C-1mg)
pkg of 5 × 1 mL (810122C-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810122C

concentration

1 mg/mL (810122C-1mg)
1 mg/mL (810122C-5mg)

shipped in

dry ice

storage temp.

−20°C

General description

1-myristoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphocholine (Acyl 06:0 NBD PC) comprises NBD (7-nitrobenz-2-oxa-1,3-diazol-4-yl) fluorescent probe.

Application

Acyl 06:0 NBD PC may be used:
  • as a supplement in ice-cold synthetic defined (SD) medium for yeast cultures for flow cytometry studies
  • as a fluorescent marker in hyaluronan-phospholipid based medium (HA–phospholipid medium) for culturing cartilage cells and to visualize lipid vesicle formation
  • in the preparation of small unilamellar vesicles (SUVs) and fluorescence-labeled supported lipid bilayer (SLB) for fluorescence recovery after photobleaching (FRAP) studies

Biochem/physiol Actions

Lipids that are labeled with NBD (7-nitrobenz-2-oxa-1,3-diazol-4-yl) are useful in lipid membranes dynamics studies. Acyl 06:0 NBD PC is used as yeast extract–peptone–dextrose (YPD) medium component in yeast uptake studies to decipher its incorporation.

Packaging

5 mL Amber Glass Screw Cap Vial (810122C-1mg)
5 mL Amber Glass Screw Cap Vial (810122C-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system

WGK

WGK 3

Certificates of Analysis (COA)

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Involvement of LEM3/ROS3 in the Uptake of Phosphatidylcholine with Short Acyl Chains in Saccharomyces cerevisiae
Ono Y, et al.
Bioscience, Biotechnology, and Biochemistry, 73(3), 750-752 (2009)
Directed evolution of a sphingomyelin flippase reveals mechanism of substrate backbone discrimination by a P4-ATPase
Roland BP and Graham TR
Proceedings of the National Academy of Sciences of the USA, 113(31), E4460-E4466 (2016)
Phospholipid Vesicles in Media for Tribological Studies against Live Cartilage
Veselack T, et al.
Lubrication Science, 6(1), 19-19 (2018)
Annexin-V stabilizes membrane defects by inducing lipid phase transition
Lin YC, et al.
Nature Communications, 11(1), 1-13 (2020)
Yi-Chih Lin et al.
Nature communications, 11(1), 230-230 (2020-01-15)
Annexins are abundant cytoplasmic proteins, which bind to membranes that expose negatively charged phospholipids in a Ca2+-dependent manner. During cell injuries, the entry of extracellular Ca2+ activates the annexin membrane-binding ability, subsequently initiating membrane repair processes. However, the mechanistic action of
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