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305251

Sigma-Aldrich

(S)-(−)-2-(Trifluoroacetamido)succinic anhydride

97%

Synonym(s):

(S)-(−)-2-Trifluoroacetamidosuccinic anhydride, N-Trifluoroacetyl-L-aspartic acid anhydride

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About This Item

Empirical Formula (Hill Notation):
C6H4F3NO4
CAS Number:
777-33-3
Molecular Weight:
211.10
MDL number:
MFCD00012332
UNSPSC Code:
12352005
PubChem Substance ID:
24858416
NACRES:
NA.22

Assay

97%

form

solid

optical activity

[α]20/D −28.0°, c = 1 in THF

mp

131-132 °C (lit.)

SMILES string

FC(F)(F)C(=O)N[C@H]1CC(=O)OC1=O

InChI

1S/C6H4F3NO4/c7-6(8,9)5(13)10-2-1-3(11)14-4(2)12/h2H,1H2,(H,10,13)/t2-/m0/s1

InChI key

ABTJOHYOWBAGTP-REOHCLBHSA-N

Related Categories

Application

Useful in the synthesis of 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene, a potent dopamine agonist. Used in the synthesis of sweetening agents, such as N-trifluoroacetyl-L-aspartic acid α-amides and α-anilides.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300

Precautionary Statements

P264 - P301 + P310

Hazard Classifications

Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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L-4'-Cyano-3-(2,2,2-trifluoroacetamido)succinanilic acid and related synthetic sweetening agents.
M Lapidus et al.
Journal of medicinal chemistry, 16(2), 163-166 (1973-02-01)
The Journal of Organic Chemistry, 50, 3619-3619 (1985)

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