- Bobel-24 activity against Cryptosporidium parvum in cell culture and in a SCID mouse model.
Bobel-24 activity against Cryptosporidium parvum in cell culture and in a SCID mouse model.
Antimicrobial agents and chemotherapy (2007-12-28)
Cristina Rueda, Soledad Fenoy, Fernando Simón, Carmen Del Aguila
PMID18160525
ABSTRACT
The anticryptosporidial activity of Bobel-24 (2,4,6-triiodophenol) was studied for the first time, resulting in a reduction of the in vitro growth of Cryptosporidium of up to 99.6%. In a SCID mouse model of chronic cryptosporidiosis, significant differences (P < 0.05) in oocyst shedding were observed in animals treated with 125 mg/kg/day. These results merit further investigation of Bobel-24 as a chemotherapeutic option for cryptosporidiosis.
MATERIALS