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Key Documents

SML1370

Sigma-Aldrich

A-779 trifluoroacetate salt

≥98% (HPLC)

Synonym(s):

A779 trifluoroacetate salt, Asp1-Arg2-Val3-Tyr4-Ile5-His6-D-Ala7, D-Ala7-Ang-(1-7), DRVYIHA (Modification: Ala-7 = D-Ala), DRVYIHa trifluoroacetate salt, H-Asp-Arg-Val-Tyr-Ile-His-D-Ala-OH trifluoroacetate salt, [7-D-ALA]-angiotensin-(1-7) trifluoroacetate salt

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About This Item

Empirical Formula (Hill Notation):
C39H60N12O11 · xC2HF3O2
CAS Number:
159432-28-7
Molecular Weight:
872.97 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

lyophilized powder

color

white to off-white

shipped in

wet ice

storage temp.

−20°C

Biochem/physiol Actions

A-779 (D-Ala7-Ang-(1-7)) is a potent and selective antagonist of angiotensin (1-7), an endogenous peptide that acts through activation of a non-AT1, non-AT2 receptor, Mas, and opposes the activity of angiotensin. A-779 has an IC50 of 0.3 nM for Mas with negligible affinity for either AT1R or AT2R.
This blocking angiotensin action affects cardiovascular function.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cardiovascular actions of angiotensin-(1-7)
Ferreira AJ and Santos RAS
Brazilian journal of medical and biological research, 38(4), 499-507 (2005)
Gustavo B Lamy et al.
Frontiers in physiology, 12, 682711-682711 (2021-07-30)
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