8.52340

N-Biotinyl-NH(PEG)11-COOH

Novabiochem^®

• Synonym(s): N-Biotinyl-NH(PEG)11-COOH, O-[2-(Biotinylamino)ethyl]-OÆ-(2-carboxyethyl)undecaethylene glycol
• Empirical Formula (Hill Notation): C₃₇H₆₉N₃O₁₆S
• Molecular Weight: 844.02
• UNSPSC Code: 12352106
• NACRES: NA.22

Properties

• Quality Level: 200
• product line: Novabiochem^®
• Assay: ≥98% (TLC)
• form: powder
• reaction suitability: reaction type: Biotinylations
• manufacturer/tradename: Novabiochem^®
• application(s): peptide synthesis
• storage temp.: 15-25°C

Description

General description

The use of this novel biotin derivative incorporates a hydrophilic 40 atom PEG spacer between the peptide and biotin. This not only greatly improves the solubility of the resultant peptide, but reduces steric hindrance between the peptide and biotin, leading to better avidin binding and higher biological activity. The biotin-PEG derivative can be easily incorporated using any standard coupling method as the final step in SPPS, immediately prior to cleavage of the peptide from the resin.

Associated Protocols and Technical Articles
Biotinylation Reagents for Peptide Synthesis

Analysis Note

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(CMA2)): ≥ 98 %
Identity (LC-MS): 843.0 - 845.0 g/mol

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable