878110C

C16-02:0 PC

Avanti Research^™ - A Croda Brand 878110C

• Synonym(s): 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine
• Empirical Formula (Hill Notation): C₂₆H₅₄NO₇P
• CAS Number: 74389-68-7
• Molecular Weight: 523.68
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• form: liquid
• packaging: pkg of 1 × 1 mL (878110C-5mg); pkg of 1 × 2.5 mL (878110C-25mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 878110C
• concentration: 10 mg/mL (878110C-25mg); 5 mg/mL (878110C-5mg)
• lipid type: bioactive lipids; phosphoglycerides
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(C)=O)COCCCCCCCCCCCCCCCC)=O
• InChI: 1S/C26H54NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5/h26H,6-24H2,1-5H3/t26-/m1/s1
• InChI key: HVAUUPRFYPCOCA-AREMUKBSSA-N

Description

General description

C16-02:0 PC, also known as 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (C16 PAF) (acetyl PAF), is a platelet-activating factor (PAF). Acetyl PAF is present in the body and it contains ether-linked hexadecyl chain at the sn-1 position and an acetyl group at the sn-2 position.

Application

C16-02:0 PC or 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine, a platelet-activating factor (PAF) is used as a substrate for the determination of platelet-activating factor-acetylhydrolase (PAF-AH) activity in plasma or serum.

Biochem/physiol Actions

Platelet-activating factor (PAF) is a pro-inflammatory agent that exhibits variety of biological and pharmacological effects. It plays a major role in initiation and progression of atherosclerosis. PAF acts as a potential biomarker for coronary artery diseases. It yields LysoPAF (1-O-alkyl-2-hydroxy-sn-glycero-3-phosphocholine) on hydrolysis by platelet-activating factor-acetylhydrolase.

Packaging

5 mL Clear Glass Sealed Ampule (878110C-25mg)

5 mL Clear Glass Sealed Ampule (878110C-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H302,H315,H319,H331,H336,H351,H361d,H372
• Precautionary Statements: P202 - P301 + P312 - P302 + P352 - P304 + P340 + P311 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
• Target Organs: Liver,Kidney, Respiratory system
• Storage Class Code: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3
• Flash Point(F): does not flash
• Flash Point(C): does not flash