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Sigma-Aldrich

Nicotinic acid-(ring-d4)

≥98 atom % D, ≥98% (CP)

Synonym(s):

3-Pyridine-d4-carboxylic acid, Niacin-(ring-d4), Vitamin B3 (ring-d4)

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About This Item

Empirical Formula (Hill Notation):
C6D4HNO2
CAS Number:
66148-15-0
Molecular Weight:
127.13
MDL number:
MFCD00190491
UNSPSC Code:
12352106
PubChem Substance ID:
24871967
NACRES:
NA.12

isotopic purity

≥98 atom % D

Assay

≥98% (CP)

form

powder

technique(s)

mass spectrometry (MS): suitable
protein expression: suitable

color

white

mp

236-239 °C (lit.)

mass shift

M+4

SMILES string

[2H]c1nc([2H])c(c([2H])c1[2H])C(O)=O

InChI

1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)/i1D,2D,3D,4D

InChI key

PVNIIMVLHYAWGP-RHQRLBAQSA-N

General description

Nicotinic acid (pyridine-3-carboxylic acid) is also known as niacin or vitamin B3. It is a water-soluble vitamin found in some vegetable and animal sources. Niacin is also a precursor for the synthesis of NAD and NADP.

Application

Nicotinic acid-(ring-d4) can be used as an internal standard for the quantification of nicotinic acid in the biological sample by gas chromatography-mass spectrometry (GC-MS). It can be also used as a precursor for the preparation of N′-nitrosonornicotine-2,4,5,6-d4 derivative.

Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Niacin and cholesterol: role in cardiovascular disease
Ganji SH, et al.
The Journal of Nutritional Biochemistry, 14(6), 298-305 (2003)
Synthesis of nornicotine-2, 4, 5, 6-d4 and its N?-nitroso derivative
Munson JW and Hodgkins TG
Journal of Labelled Compounds & Radiopharmaceuticals, 13(4), 461-469 (1977)
Concurrent quantification of quinolinic, picolinic, and nicotinic acids using electron-capture negative-ion gas chromatography-mass spectrometry
Smythe GA, et al.
Analytical biochemistry, 301(1), 21-26 (2002)
Niacin, Nicotinamide, and Nicotinic Acid
Van A and Susan D
Kirk-Othmer Encyclopedia of Chemical Technology, 349, 4379-4379 (2000)
Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117 411 patients
Keene D, et al.
BMJ (Clinical Research ed.), 349, 4379-4379 (2014)

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