42602

Propionyl-L-carnitine

≥94.0% (HPLC), suitable for LC/MS

• Synonym(s): (2R)-3-Carboxy-N,N,N-trimethyl-2-(1-oxopropoxy)-1-propanaminium inner salt, L-Carnitine propionyl ester, C3-Carnitine, Propanoyl-L-carnitine
• Empirical Formula (Hill Notation): C₁₀H₁₉NO₄
• CAS Number: 20064-19-1
• Molecular Weight: 217.26
• MDL number: MFCD00870024
• UNSPSC Code: 12352209
• PubChem Substance ID: 329756246
• NACRES: NA.26

Properties

• product name: Propionyl-L-carnitine, ≥94.0% (HPLC)
• Quality Level: 100
• Assay: ≥94.0% (HPLC)
• form: powder or crystals
• optical activity: [α]/D -23±3°, c = 1 in H₂O
• technique(s): LC/MS: suitable
• impurities: ≤10% water (calcd. from elemental analysis)
• color: white to off-white
• storage temp.: 2-8°C
• SMILES string: [O-]C(C[C@@H](OC(CC)=O)C[N+](C)(C)C)=O
• InChI: 1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3/t8-/m1/s1
• InChI key: UFAHZIUFPNSHSL-MRVPVSSYSA-N

Description

General description

Propionyl-L-carnitine (PLC) is a short-chain fatty acid ester derivative of carnitine.

Application

Propionyl-L-carnitine has been used as a standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS).

Biochem/physiol Actions

Propionyl-L-carnitine (PLC) plays a key role in lipid and carbohydrate metabolism. It provides substrates to the ischemic muscle for energy production and ATP generation. PLC has the potential to treat severe peripheral arterial disease and chronic heart failure. It is present in high abundance in the urine of patients with methylmalonyl-CoA mutase (MUT) deficiency, together with methylmalonic acid. MUT is a mitochondrial enzyme that catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable