- Organotypic brain explant culture as a drug evaluation system for malignant brain tumors.
Organotypic brain explant culture as a drug evaluation system for malignant brain tumors.
Cancer medicine (2017-10-06)
Noriaki Minami, Yusuke Maeda, Shunsuke Shibao, Yoshimi Arima, Fumiharu Ohka, Yutaka Kondo, Koji Maruyama, Masatoshi Kusuhara, Takashi Sasayama, Eiji Kohmura, Hideyuki Saya, Oltea Sampetrean
PMID28980419
ABSTRACT
Therapeutic options for malignant brain tumors are limited, with new drugs being continuously evaluated. Organotypic brain slice culture has been adopted for neuroscience studies as a system that preserves brain architecture, cellular function, and the vascular network. However, the suitability of brain explants for anticancer drug evaluation has been unclear. We here adopted a mouse model of malignant glioma based on expression of H-Ras
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