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  • The cell-autonomous role of excitatory synaptic transmission in the regulation of neuronal structure and function.

The cell-autonomous role of excitatory synaptic transmission in the regulation of neuronal structure and function.

Neuron (2013-05-15)
Wei Lu, Eric A Bushong, Tiffany P Shih, Mark H Ellisman, Roger A Nicoll
PMID23664612
ABSTRACT

The cell-autonomous role of synaptic transmission in the regulation of neuronal structural and electrical properties is unclear. We have now employed a genetic approach to eliminate glutamatergic synaptic transmission onto individual CA1 pyramidal neurons in a mosaic fashion in vivo. Surprisingly, while electrical properties are profoundly affected in these neurons, as well as inhibitory synaptic transmission, we found little perturbation of neuronal morphology, demonstrating a functional segregation of excitatory synaptic transmission from neuronal morphological development.

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