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  • Quinoline Containing Side-chain Antimalarial Analogs: Recent Advances and Therapeutic Application.

Quinoline Containing Side-chain Antimalarial Analogs: Recent Advances and Therapeutic Application.

Current topics in medicinal chemistry (2020-01-28)
Mukesh C Joshi, Timothy J Egan
ABSTRACT

The side-chains of quinoline antimalarial agents are the major concern of focus to build novel and efficaciaous bioactive and clinical antimalarials. Bioative antimalarial analogs may play a critical role in pH trapping in the food vacuole of RBC's with the help of fragmented amino acid, thus lead to Ī²-hematin inhibition. Here, the authors tried to summarize a useful, comprehensive compilation of side-chain modified ACQs along with their synthesis, biophysical and therapeutic applications etc. of potent antiplasmodial agents and therefore, opening the door towards the potential clinical status.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
meso-Tetraphenylporphyrin, BioReagent, suitable for fluorescence, ā‰„99.0% (HPLC)
Sigma-Aldrich
3,4,5,6-Tetrachlorophthalimide, 97%