SML3761
BRD7586
≥98% (HPLC)
Synonym(s):
3-[(4-Chlorophenyl)sulfonyl]-N-[4-(4-pyridinyl)-2-thiazolyl]propanamide
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About This Item
Empirical Formula (Hill Notation):
C17H14ClN3O3S2
Molecular Weight:
407.89
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
BRD7586 is a cell-permeable, and potent anti-CRISPR agent. BRD7586is a potent and selective inhibitor of SpCas9. It potently inhibits SpCas9 in both HEK293T and U2OS.eGFP.PEST cells without altering its expression, or induction of cytotoxicity. BRD7586 enhanced the specificity of SpCas9. BRD7586 inhibits genome editing at diverse endogenous loci. It is twofold more potent than BRD0539.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules
Nature Cell Biology, 24(12), 1766-1775 (2022)
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