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M6514

Sigma-Aldrich

3-(Trimethoxysilyl)propyl methacrylate

≥97%

Synonym(s):

Silane A174, [3-(Methacryloyloxy)propyl]trimethoxysilane

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About This Item

Linear Formula:
H2C=C(CH3)CO2(CH2)3Si(OCH3)3
CAS Number:
2530-85-0
Molecular Weight:
248.35
Beilstein:
1952435
EC Number:
219-785-8
MDL number:
MFCD00008593
UNSPSC Code:
47101511
PubChem Substance ID:
24897091
NACRES:
NA.56
Pricing and availability is not currently available.

Quality Level

100

Assay

≥97%

form

liquid

refractive index

n20/D 1.431 (lit.)

bp

190 °C (lit.)

density

1.045 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

CO[Si](CCCOC(=O)C(C)=C)(OC)OC

InChI

1S/C10H20O5Si/c1-9(2)10(11)15-7-6-8-16(12-3,13-4)14-5/h1,6-8H2,2-5H3

InChI key

XDLMVUHYZWKMMD-UHFFFAOYSA-N

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General description

3-(Trimethoxysilyl)propyl methacrylate (TMSPMA) is a hydrophobic monomer.[1] The presence of an additional functional group of acrylate facilitates TMSPMA for grafting polymerization on plastic surfaces.[2] 3-(Trimethoxysilyl)propyl methacrylate undergoes first-order kinetic polymerization to form polyTMSPMA, which is a moisture stable polymer.[3]

Application

3-(Trimethoxysilyl)propyl methacrylate has been used in the following applications:
  • Isoelectric focusing can lead to pH gradient formation resulting in the swelling or shrinking of gel casts. This can be prevented by using 3-(Trimethoxysilyl)propyl methacrylate to link polyacrylamide gels to glass plates covalently.[4]
  • In situ hybridization using 3-(Trimethoxysilyl)propyl methacrylate along with poly-L-lysine is a faster and durable method to attach cells, microscopic sections, and total organs to slides/other glass surfaces.[5]
  • 3-(Trimethoxysilyl)propyl methacrylate is also used in the preparation of organic/inorganic hybrid nanomaterials.[6]

Packaging

A product Information sheet is supplied which describes procedures for using this product.

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Description
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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

197.6 °F - closed cup

Flash Point(C)

92 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCT4433
MKCR5502
MKCK3155
MKCG8995
MKBX0874V

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Improvements of DNA sequencing gels.
H Garoff et al.
Analytical biochemistry, 115(2), 450-457 (1981-08-01)
Preparation of organic/inorganic hybrid nanomaterials using aggregates of poly (stearyl methacrylate)-b-poly (3-(trimethoxysilyl) propyl methacrylate) as precursor.
Junfeng Zhou.
Eur. Polymer J., 5, 1736-1743 (2007)
Saisneha Koppaka et al.
Micromachines, 12(9) (2021-09-29)
Micro-blade design is an important factor in the cutting of single cells and other biological structures. This paper describes the fabrication process of three-dimensional (3D) micro-blades for the cutting of single cells in a microfluidic "guillotine" intended for fundamental wound
ATRP of 3-(triethoxysilyl)propyl methacrylate and preparation of ?stable? gelable block copolymers
Ming Xiong
European Polymer Journal, 44, 3835-3841 (2008)
Sean Brahim et al.
Biomacromolecules, 4(5), 1224-1231 (2003-09-10)
An amphiphilic hydrogel of poly(2-hydroxyethyl methacrylate) cross-linked with tetraethyleneglycol diacrylate (TEGDA) was synthesized to contain the hydrophobic monomer 3-(trimethoxy-silyl) propyl methacrylate (PMA) and the pH-responsive, hydrophilic monomer N',N'-dimethylaminoethyl methacrylate (DMAEMA). The gels were separately loaded with two biomolecular probes, insulin
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Questions

  1. How stable is this product? How many years will it be good if kept at 2 degrees C?

    1 answer

    1. The product remains active for at least 2 years. This product will react with water since alkylsilanes react with hydroxyl groups. An ethanol solution remains active for one day. For more information please see this data sheet: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/139/774/m6514pis.pdf.

      The product specification sheet for this product contains a recommended retest date period of two years after the quality release date. A recommended retest date is the period of time during which the product is expected to remain within established stability specifications, provided that it has been stored under defined conditions. After the Retest Date, product samples should be examined to ensure that the product is still in compliance with the established specifications. For more information, you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management/quality-services.

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