5.04359

Palmitoylethanolamide

• Synonym(s): Palmitoylethanolamide, N-(2-Hydroxyethyl)hexadecanamide, PEA, Palmidrol
• Empirical Formula (Hill Notation): C₁₈H₃₇NO₂
• CAS Number: 544-31-0
• Molecular Weight: 299.49
• MDL number: MFCD00020562
• UNSPSC Code: 51111800
• NACRES: NA.77

Properties

• Assay: ≥99% (HPLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 20 mM
• storage temp.: −20°C
• InChI: 1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)19-16-17-20/h20H,2-17H2,1H3,(H,19,21)
• InChI key: HXYVTAGFYLMHSO-UHFFFAOYSA-N

Description

General description

An endogenous lipid that acts as a selective agonist for GPR55 receptors (EC₅₀ = 4, 19 800 and >30 000 nM at GPR55, CB₂ and CB₁ receptors respectively). Producing robust anti-inflammatory actions by activating PPARα (EC₅₀ = 3 µM).

Biochem/physiol Actions

Primary Target
GPR55 receptor

Warning

Toxicity: Standard Handling (A)

Preparation Note

Slight warming is required for complete solubilization.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Griffin, G., et al. 2000. J. Pharmacol. Exp. Ther.292, 886.

Lambert, D., et al. 2001. Epilepsia.42, 321.
Lambert, D., et al. 2002. Curr. Med. Chem.9, 663.
Lo Verme, J., et al. 2005. Life Sci.77, 1685.
Re, G., et al. 2005. Vet. J.173, 21.
Ryberg, R., et al. 2007. Br. J. Pharmacol.152, 1092.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS05,GHS09
• Signal Word: Danger
• Hazard Statements: H315 - H318 - H411
• Precautionary Statements: P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Hazard Classifications: Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable