575001

α-Synuclein, Human, Recombinant, E. coli

• Synonym(s): NACP
• UNSPSC Code: 12352202
• NACRES: NA.77

Properties

• biological source: human
• Quality Level: 100
• recombinant: expressed in E. coli
• Assay: ≥95% (SDS-PAGE)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; avoid repeated freeze/thaw cycles
• suitability: suitable for molecular biology
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... SNCA(6622)

Description

General description

Research area: Neuroscience

Recombinant, human α-synuclein expressed in E. coli. α-Synuclein is an acidic neuronal protein of 140 amino acids (amino acid residues 1 -140).

Application

α-Synuclein, Human, Recombinant, E. coli has been used to enhance the filter trap assay for identification of aggregated alpha-synuclein in brain samples.

Biochem/physiol Actions

α-Synuclein been implicated in the pathogenesis of Parkinson’s disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells.

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Physical form

In 100 mM NaCl, 20 mM Tris-HCl, 1 mM MgCl₂, pH 7.5.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Kahle, P.J, et al. 2001. Am. J. Pathol.159, 2215.
Kim, J. 1997. Mol. Cells7, 78.
Paik, S.R. 1997. Arch. Biochem. Biophys.344, 325.
Jakes, R., et al. 1994. FEBS Lett.345, 27.
Ueda, K., et al. 1993. Proc. Natl. Acad. Sci. USA90, 11282.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable