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T8703

Sigma-Aldrich

T0070907

≥98% (HPLC)

Synonym(s):

2-Chloro-5-nitro-N-4-pyridinyl-benzamide, Benzamide, 2-chloro-5-nitro-N-4-pyridinyl-

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About This Item

Empirical Formula (Hill Notation):
C12H8ClN3O3
CAS Number:
313516-66-4
Molecular Weight:
277.66
MDL number:
MFCD00121849
UNSPSC Code:
12352203
PubChem Substance ID:
329826884
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: >10 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

[O-][N+](=O)c1ccc(Cl)c(c1)C(=O)Nc2ccncc2

InChI

1S/C12H8ClN3O3/c13-11-2-1-9(16(18)19)7-10(11)12(17)15-8-3-5-14-6-4-8/h1-7H,(H,14,15,17)

InChI key

FRPJSHKMZHWJBE-UHFFFAOYSA-N

General description

T0070907 has antimicrotubule, antitumor and radiosensitizing properties. It decreases tubulin protein levels, which is associated with cell cycle arrest, apoptosis and also reduces metastasis of colorectal carcinoma cells. T0070907 is used as a therapeutic target in breast cancer. It stimulates proteasome-dependent degradation of tubulin.

Application

T0070907 has been used to reduce peroxisome proliferator-activated receptor gamma (PPAR-γ) expression in lipopolysaccharide (LPS)-induced leukemia RAW264.7 cell line. It also has been used to evaluate the involvement of wogonin in alleviating EtOH (ethanol)-induced inflammation in RAW264.7 cell line.
T0070907 or Benzamide has been used as a ADP-ribosyltransferase (ADPRT) inhibitor in rat hippocampal slices. It has also been used for urine analysis in patients diagnosed with acute uncomplicated urinary tract infection.

Biochem/physiol Actions

T0070907 is very similar in structure and activity to the PPAR-γ antagonist GW9662. T0070907 is more potent and has higher selectivity for PPAR-γ over all other subtypes (about 800-fold) whereas GW9662 has been reported to have some PPAR-α agonist activity.

Features and Benefits

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

T0070907 is soluble in DMSO at a concentration that is greater than 10 mg/ml.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hyperin attenuates inflammation by activating PPAR-gamma in mice with acute liver injury (ALI) and LPS-induced RAW264. 7 cells
Huang C, et al.
International Immunopharmacology, 29(2), 440-447 (2015)
T0070907 inhibits repair of radiation-induced DNA damage by targeting RAD51
An Z, et al.
Toxicology in vitro, 37, 1-8 (2016)
Alexandros K Pavlou et al.
Biosensors & bioelectronics, 17(10), 893-899 (2002-09-24)
The use of volatile production patterns produced by bacterial contaminants in urine samples were examined using electronic nose technology. In two experiments 25 and 45 samples from patients were analysed for specific bacterial contaminants using agar culture techniques and the
The PPARgamma antagonist T0070907 suppresses breast cancer cell proliferation and motility via both PPARgamma-dependent and-independent mechanisms
Zaytseva YY, et al.
Anticancer Research, 31(3), 813-823 (2011)
Wogonin attenuates inflammation by activating PPAR-gamma in alcoholic liver disease
Li HD, et al.
International Immunopharmacology, 50, 95-106 (2017)
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