SAB4503015

Anti-p53 antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Antigen NY-CO-13, Cellular tumor antigen p53, Phosphoprotein p53, TP53, tumor protein p53
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 43 kDa
• species reactivity: mouse, human, rat
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:10000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: P04637
• UniProt accession no.: P04637
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... TP53(7157)

Description

General description

Anti-p53 Antibody detects endogenous levels of total p53 protein.

TP53 gene is mapped to human chromosome 17p13.1.

Immunogen

The antiserum was produced against synthesized peptide derived from human p53.

Immunogen Range: 283-332

Biochem/physiol Actions

TP53 gene is involved in the regulation of cell cycle, senescence and apoptosis upon oncogene activation, stress and DNA damage. Therefore, the gene has anti-tumor activity initiation and prevents tumor progression. Mutation in TP53 is known to be the major cause of almost half of all human malignancy. Breast cancer is one such condition in which, the disease development is severe due to mutation in TP53 gene.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable