S1515
Anti-Spectrin antibody produced in rabbit
whole antiserum
Synonym(s):
Anti-EL2, Anti-HPP, Anti-HS3, Anti-SPH3, Anti-SPTA
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About This Item
Recommended Products
biological source
rabbit
conjugate
unconjugated
antibody form
whole antiserum
antibody product type
primary antibodies
clone
polyclonal
contains
15 mM sodium azide
species reactivity
human
technique(s)
western blot: 1:400
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SPTA1(6708) , SPTB(6710) , SPTBN1(6711) , SPTBN2(6712) , SPTBN4(57731) , SPTBN5(51332)
General description
Spectrin is a multifunctional protein that has lipid-binding sites within CH (calponin-homology) tandem domains, a PH (pleckstrin homology) domain and triple helical segments. It is located on chromosome 1q23.1.
Spectrin is the major cytoskeletal component in erythrocytes. It is composed of two types of polypeptides known as α and β with molecular weights of 240 and 220 kDa, respectively. The α- and β-chains form heterotetramers which are linked end-to-end via oligomeric actin and band 4.1 protein.
Specificity
The antibody reacts specifically with the α and β chains of human erythrocyte spectrin.
Immunogen
spectrin from freshly prepared human erythrocyte ghosts.
Application
Anti-Spectrin antibody has been used in western blotting immunofluorescence and immunostaining.
Biochem/physiol Actions
Spectrins modulates the cell morphology and mechanical properties. Spectrins also participates in the cell cycle by controlling the upregulation of membrane receptors. α- and β spectrins are essential for the development of nervous system.
The spectrin-based membrane skeleton is essential to provide mechanical stability and membrane integrity. It is also responsible for protein organization, trafficking and resilience of erythrocytes.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Physiologically important secondary modifications of red cell membrane in hereditary spherocytosis-evidence for in vivo oxidation and lipid rafts protein variations
Margetis P, et al.
Blood Cells, Molecules and Diseases, 38(3), 210-220 (2007)
Natalie J Spillman et al.
Cellular microbiology, 19(6) (2017-01-10)
The malaria parasite exports numerous proteins into its host red blood cell (RBC). The trafficking of these exported effectors is complex. Proteins are first routed through the secretory system, into the parasitophorous vacuole (PV), a membranous compartment enclosing the parasite.
A Choudhury et al.
Parasitology research, 83(8), 746-754 (1997-01-01)
Identification of neo-antigenic determinant(s) on parasite infected cell surface is important to control intracellular infections. Such determinant(s) on the surface of intact Plasmodium berghei infected erythrocytes have not been conclusively demonstrated. To generate polyclonal antiserum selectively recognizing the parasite infected
Chanjae Lee et al.
Development genes and evolution, 219(6), 319-330 (2009-06-26)
One contributing factor in the worldwide decline in amphibian populations is thought to be the exposure of eggs to UV light. Enrichment of pigment in the animal hemisphere of eggs laid in the sunlight defends against UV damage, but little
Transgenic overexpression of caveolin-3 in skeletal muscle fibers induces a Duchenne-like muscular dystrophy phenotype
Galbiati F, et al.
Proceedings of the National Academy of Sciences of the USA, 97(17), 9689-9694 (2000)
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