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Key Documents

MAB3482

Sigma-Aldrich

Anti-Cystic Fibrosis Transmembrane Conductance Regulator Antibody, clone MM13-4

clone MM13-4, Chemicon®, from mouse

Synonym(s):

CFTR

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

MM13-4, monoclonal

species reactivity

human

should not react with

mouse, shark

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... CFTR(1080)

Specificity

Human cystic fibrosis transmembrane conductance regulator (CFTR). Recognizes an epitope at the N-terminal between residues 24 and 35.

Immunogen

Synthetic peptide (RKGYRQRLELSD) corresponding to residues 25-36 of human cystic fibrosis transmembrane conductance regulator (CFTR).

Application

Detect Cystic Fibrosis Transmembrane Conductance Regulator using this Anti-Cystic Fibrosis Transmembrane Conductance Regulator Antibody, clone MM13-4 validated for use in IC, IP & WB.
Research Category
Neuroscience
Research Sub Category
Ion Channels & Transporters
Western blot: 10 μg/mL, recognizes CFTR (150-170kDa) and two additional proteins at 52kDa and 38kDa

Immunoprecipitation

Immunofluorescence

Note: Does not work on paraffin embedded tissue.

Optimal working dilutions must be determined by the end user.

Physical form

Format: Purified
Purified immunoglobulin. Liquid in 0.02 M Phosphate buffer, 0.25 M NaCl, pH 7.6 with 0.1% sodium azide.

Storage and Stability

Maintain at 2-8°C in undiluted aliquots up to 6 months.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cysteine string protein interacts with and modulates the maturation of the cystic fibrosis transmembrane conductance regulator.
Zhang, H; Peters, KW; Sun, F; Marino, CR; Lang, J; Burgoyne, RD; Frizzell, RA
The Journal of Biological Chemistry null
Shipeng Wei et al.
The Journal of biological chemistry, 289(29), 19942-19957 (2014-05-31)
ATP-binding cassette (ABC) transporters are an ancient family of transmembrane proteins that utilize ATPase activity to move substrates across cell membranes. The ABCC subfamily of the ABC transporters includes active drug exporters (the multidrug resistance proteins (MRPs)) and a unique
Nabila Hamdaoui et al.
British journal of pharmacology, 163(4), 876-886 (2011-03-04)
The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-dependent chloride channel in the plasma membrane of epithelia whose mutation is the cause of the genetic disease cystic fibrosis (CF). The most frequent CFTR mutation is deletion of Phe(508) and
Ahmed Lazrak et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(11), 4630-4645 (2013-08-03)
The most common disease-causing mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene is the out-of-frame deletion of 3 nucleotides (CTT). This mutation leads to the loss of phenylalanine-508 (ΔF508) and a silent codon change (SCC) for isoleucine-507 (I507-ATC→ATT).
Hong Yu Ren et al.
Molecular biology of the cell, 24(19), 3016-3024 (2013-08-09)
Cystic fibrosis (CF) is a fatal genetic disorder associated with defective hydration of lung airways due to the loss of chloride transport through the CF transmembrane conductance regulator protein (CFTR). CFTR contains two membrane-spanning domains (MSDs), two nucleotide-binding domains (NBDs)

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