764825
Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)
PEG Mn 2,000, PLGA Mn 4,500
Synonym(s):
PEG-PLGA, Polyethylene glycol, mPEG-b-PLGA
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About This Item
Linear Formula:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
UNSPSC Code:
12162002
NACRES:
NA.23
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form
pellets
feed ratio
lactide:glycolide 65:35
mol wt
PEG Mn 2,000
PLGA Mn 4,500
average Mn 6,500 (total)
degradation timeframe
1-4 weeks
transition temp
Tm 241-246 °C
PDI
≤2.0
storage temp.
2-8°C
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General description
Amphiphilic block copolymers (AmBC) are made up of two chemically different homopolymer blocks. One of the block is hydrophilic and the other one is hydrophobic. These macromolecules have the properties to self-assemble when dissolved in an aqueous media. PEG-PLGA is one the most commonly used biodegradable amphiphilic block copolymers for drug delivery applications. PEG is the hydrophilic part and PLGA is the hydrophobic part.
Application
Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.
forming "stealth" pegylated microparticles
Features and Benefits
- Good biocompatibility, low immunogenicity and good degradability.
- Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release of drugs. Despite nearly three decades of research, approaches to reproducibly formulate targeted NPs with the optimal biophysicochemical properties have remained
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