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731765

Sigma-Aldrich

Poly(ethylene glycol) methyl ether maleimide

average Mn 2,000, maleimide, methoxy, chemical modification reagent thiol reactive

Synonym(s):

Polyethylene glycol, Methoxy PEG maleimide, PEG methyl ether maleimide

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About This Item

Linear Formula:
CH3O(CH2CH2O)nCH2CH2OC(O)CH2CH2CH2N[C(O)]2CHCH
UNSPSC Code:
12162002
NACRES:
NA.23

product name

Poly(ethylene glycol) methyl ether maleimide, average Mn 2,000

form

solid

mol wt

average Mn 2,000

reaction suitability

reagent type: chemical modification reagent
reactivity: thiol reactive

mp

48-52 °C

Mw/Mn

<1.1

Ω-end

maleimide

α-end

methoxy

polymer architecture

shape: linear
functionality: monofunctional

Application

Poly(ethylene glycol) methyl ether maleimide is a maleimide-functionalized poly(ethylene glycol). Due to the maleimide-functionalization, this material can be used to rapidly conjugate thiol-containing biomolecules, APIs, or targeting ligands.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Karina L Heredia et al.
Macromolecules, 42(7), 2360-2367 (2009-01-01)
In this report we describe a straightforward approach to synthesize polymers with end-groups that bind site-specifically to two different proteins. Telechelic biotin, maleimide poly(N-isopropylacrylamide) (pNIPAAm) was synthesized for the formation of streptavidin (SAv)-bovine serum albumin (BSA) polymer conjugates. Reversible addition-fragmentation

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