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Chemical Biology

Image of Laboratory equipment used in biochemical research of carbohydrates including monosaccharides, disaccharides, oligosaccharides, and polysaccharides.

Chemical biology products incorporate the techniques and strengths of chemistry to address fundamentally important questions in biology, medicine, and drug discovery. Sigma-Aldrich® chemical biology products provide solutions, expertise, and industry leadership to advance your research. We offer a market-leading range of innovative products for conjugation strategies, such as azide-alkyne cycloaddition chemistry, as well as synthetic intermediates and building blocks for the synthesis of biomolecules, such as peptides, carbohydrates, and oligonucleotides.   

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Carbohydrates Click Chemistry ReagentsCrosslinkersProtein Degrader Building BlocksChemical Biology Tools
The image depicts a 3D molecular model with nine red and seven black atoms representing oxygen and carbon

Carbohydrates

Our broad portfolio of highly pure carbohydrates are used widely as supplements to cell culture media and as building blocks in glycan and glycoconjugate synthesis.

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Click Chemistry Reagents

Our portfolio of click chemistry reagents includes a variety of azides, alkynes, catalysts, and ligands to accelerate your progress in chemical biology, polymer chemistry, bioconjugation, and drug discovery.

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This example of click chemistry scheme shows the Copper(I)-catalyzed Azide-Alkyne Cycloaddition (CuAAC)of alkynes to azides to form 1,4-disubsituted-1,2,3-triazole

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The image depicts a colorful biochemical diagram illustrating the bioconjugation process where two blue spiky shapes labeled “Protein Protein Interaction” are transformed into a “Crosslinked Proteins” shape through the action of a “Crosslinker.”
Crosslinkers

Our portfolio of linkers and crosslinkers provide structural stability and reliability in protein-protein, protein-peptide, and peptide/protein-small molecule interactions for all your bioconjugation needs.

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The image displays a complex, multi-colored molecular structure with a detailed view of atomic arrangements in green and blue, highlighting the intricate connections within the molecule.
Protein Degrader Building Blocks

Our protein degrader building blocks are the easiest way to generate libraries of protein degraders, such as proteolysis targeting chimeras (PROTAC® molecules), that can be screened for effective degradation of your target protein from cells.

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A scientist in a lab coat and blue gloves is examining a detailed blue 3D model of a molecular structure with blurred laboratory equipment in the background.
Chemical Biology Tools

Our chemical biology tools incorporate techniques and strengths of chemistry to address fundamentally important research in biology, medicine, and drug discovery. 

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Related Categories
Solid Formulation: Excipients Used in Pharmaceutical Dosage Forms
Our comprehensive portfolio of high-quality raw materials and functionalized excipients helps you meet the challenges of solid formulation pharmaceutical manufacturing, backed by regulatory support for simplified supplier qualification, accelerated processes, and reduced total cost of ownership.
Lab Chemicals
Our vast lab chemicals portfolio includes acids, salts, caustic alkalis, bases, metals, and solvents for a variety of applications, including research, quality control, and other analytical testing.
Chemical Building Blocks
Explore diverse organic building blocks for seamless synthesis, including Baran functionalized & hindered amine reagents. Tailor to your targets.
Chemical Synthesis
Browse our selection of synthetic chemistry products, including coupling, halogenation, Grignard, oxidation, protection, deprotection, reduction, organoaluminium, and organosilicon reagents.
Flavors & Fragrances
Explore our selection of aroma raw materials including certified food grade, IFRA, natural, kosher and halal ingredients with a large organoleptic range and with quality and regulatory documentation.
Greener Alternative Products
Greener Alternative Products promote sustainability in chemistry, aligning with Green Chemistry Principles and Design for Sustainability.
Stable Isotopes
ISOTEC® Stable Isotopes are stable isotope compounds, ranging from gases to complex molecules, that are useful for tracer studies in proteomics and metabolomics, agents for MRI / MRS, and in a wide range of other biomedical applications.
Biochemicals
We offer a large selection of competatively priced, high-quality biochemicals, including buffers, detergents, agarose, lipids, antibiotics, metabolites, vitamins, and coenzymes.
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