T7675
Tau Proteins from bovine brain
>90% (SDS-PAGE), lyophilized powder
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About This Item
assay
>90% (SDS-PAGE)
form
lyophilized powder
UniProt accession no.
Storage temp.
2-8°C
Gene Information
cow ... MAPT(281296)
Biochem/physiol Actions
Tau proteins are composed of several isoforms localized mainly in neuronal axons. They are stimulators of microtubule polymerization and are found in an abnormal state of phosphorylation in Alzheimer′s disease.
Packaging
Package size based on protein content
Quality
Partially phosphorylated
Physical form
Lyophilized powder containing Tris buffer salt, NaCl, EGTA, dithiothreitol and sucrose as stabilizer
Preparation Note
Purified by affinity chromatography.
Substrates
Substrate for many protein kinases.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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G Lindwall et al.
The Journal of biological chemistry, 259(19), 12241-12245 (1984-10-10)
Two newly discovered properties of tau protein are reported; it is soluble in 2.5% perchloric acid and insoluble in 25% glycerol. These properties were exploited in the development of improved methods for the purification of tau. Treatment with perchloric acid
M Mercken et al.
Journal of neurochemistry, 58(2), 548-553 (1992-02-01)
Immunoaffinity chromatography with a monoclonal antibody produced against bovine tau protein was used to purify tau proteins from human brain. Fifty grams of brain tissue yielded approximately 2 mg of pure tau proteins. The affinity-purified human tau was used to
E M Mandelkow et al.
Trends in biochemical sciences, 18(12), 480-483 (1993-12-01)
Alzheimer's Disease (AD) is an age-related dementia that has received increasing attention in recent years. The disease appears to be specific for humans and, moreover, its causes are unknown. Studies of the disease are complicated by the fact that a
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