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H4128

Sigma-Aldrich

11β-Hydroxytestosterone

crystalline

Synonym(s):

11β,17β-Dihydroxyandrost-4-en-3-one, 4-Androstene-11β,17β-diol-3-one

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About This Item

Empirical Formula (Hill Notation):
C19H28O3
CAS Number:
1816-85-9
Molecular Weight:
304.42
MDL number:
MFCD00010481
UNSPSC Code:
12352200
PubChem Substance ID:
24895621

form

crystalline

drug control

USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada

color

light yellow

SMILES string

CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C1CCC2O

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Biochem/physiol Actions

Structure-activity relationships of 11-substituted testosterone derivatives as progesterone agonists, and their effect on growth and differentiation of human decidual cells.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H351,H360

Hazard Classifications

Carc. 2 - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
056F4070

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D E Kime et al.
General and comparative endocrinology, 50(1), 105-115 (1983-04-01)
Testes of sexually mature Sarotherodon mossambicus were incubated at 15, 22, 30, and 40 degrees with (a) tritiated testosterone and (b) salmon pituitary extract. Formation of 11-keto- and 11 beta-hydroxytestosterone from the tritiated precursor showed little change in yield between
D E Kime
Toxicology letters, 22(1), 83-88 (1984-07-01)
Testes of the rainbow trout were incubated in the presence of 0, 0.05, 0.5 and 5 mM cadmium (Cd). Production of those steroids measured was stimulated by 0.05 and 0.5 mM cadmium. Yields of testosterone (T) and 11 beta-hydroxytestosterone (beta)
R Rapoport et al.
Archives of biochemistry and biophysics, 317(2), 412-416 (1995-03-10)
In the present study we examined the coupling of NADPH oxidation to substrate hydroxylation and the effects of steroids on this process in reconstituted P450scc and P450c11 systems. To determine the relative rates of substrate hydroxylation vs electron leakage we
R C Cochran
General and comparative endocrinology, 65(1), 141-148 (1987-01-01)
A technique for the simultaneous detection of serum concentrations of testosterone (T), 17 beta-hydroxy-4-androstene-3,11-dione (11-KT), and 11 beta, 17 beta-dihydroxy-4-androsten-3-one (11 beta-HT) was established using a combination of high performance liquid chromatography separation and radioimmunoassay. In the mummichog, Fundulus heteroclitus
R Schulz
General and comparative endocrinology, 64(2), 312-319 (1986-11-01)
Male rainbow trout show high plasma androgen levels beginning with the period of full spermatogenesis until the end of spermiation. The difficulties in explaining the steroid levels in regard to the concomitant changes of the plasma GTH concentrations prompted investigations
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