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F7926

Sigma-Aldrich

Anti-phospho-FAK (pTyr397) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-phospho-Focal Adhesion Kinase

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About This Item

MDL number:
MFCD03455737
UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

usage

sufficient for 10 blots

species reactivity

human, rat, mouse, Drosophila, frog

technique(s)

western blot: 1:1,000

UniProt accession no.

Q05397

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... PTK2(5747)

General description

Focal adhesion kinase (FAK) is a cytoplasmic protein that belongs to non-receptor protein tyrosine kinase family. It has a critical role in regulation of cell differentiation, migration, adhesion and acceleration of the G1 to S phase transition in cell cycle. Anti-phospho-FAK (pTyr397) antibody can be used in immunocytochemistry and immunohistochemistry. Rabbit anti- phospho-FAK (pTyr397) antibody reacts specifically with FAK (125kD) phosphorylated at tyrosine 397. This product can also react with FAK (pTyr397) of rat, chicken, frog, mouse and human.

Immunogen

synthetic phophopeptide derived from the region of FAK that contains tyrosine 397.

Application

Anti-phospho-FAK (pTyr397) antibody can be used in immunoblotting (diluted 1:1000) and microarray.

Physical form

Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 50% glycerol, 1.0 mg/ml BSA (IgG and protease free) and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J M Taylor et al.
The Journal of biological chemistry, 275(25), 19250-19257 (2000-04-06)
A variety of agonists including phenylephrine (PE) induce hypertrophy in neonatal ventricular cardiomyocytes. Here we report that signals provided by extracellular matrix proteins (ECM) augment the PE-induced hypertrophic response of cardiomyocytes and provide evidence that ECM-dependent signaling is mediated in
Potential roles for focal adhesion kinase in development.
Ridyard MS, Sanders EJ
Anat. Embryol., 199(1), 1-7 (1999)
Xuelian Tang et al.
Cancer biology & therapy, 5(11), 1474-1480 (2006-10-03)
Herein, we report that marine-derived sulfated polysaccharide (MSP), a new kind of polysaccharide extracted from brown alga, exhibits the anti-migration effect in vitro and potently suppress metastasis of Lewis lung carcinoma in vivo. Adhesion assays demonstrated that MSP inhibits the
Sean E Gill et al.
Developmental biology, 298(2), 540-554 (2006-08-08)
Tissue inhibitors of metalloproteinases (TIMPs) regulate extracellular matrix (ECM) degradation by matrix metalloproteinases (MMPs) throughout embryogenesis. We examined lungs from TIMP3 null mice and found decreased bronchiole branching, enhanced activity of MMPs and enhanced fibronectin degradation throughout lung development compared
J D Owen et al.
Molecular and cellular biology, 19(7), 4806-4818 (1999-06-22)
Focal adhesion kinase (FAK) is a nonreceptor protein tyrosine kinase involved in integrin-mediated control of cell behavior. Following cell adhesion to components of the extracellular matrix, FAK becomes phosphorylated at multiple sites, including tyrosines 397, 576, and 577. Tyr-397 is
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