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F5804

Sigma-Aldrich

Anti-FBG3 (FBXO44) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-F Box 3

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About This Item

MDL number:
MFCD08705455
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~30 kDa by calculation

species reactivity

human

technique(s)

western blot: 1:500-1:1,000

UniProt accession no.

Q9H4M3

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... FBXO44(93611)
mouse ... Fbxo44(230903)
rat ... Fbxo44(500587)

Immunogen

peptide corresponding to the human FBG3 protein (amino acids 103-119). This sequence has 94% homology with mouse and rat.

Application

Anti-FBG3 (FBXO44) antibody is suitable for western blot: 1:500-1:1,000.

Biochem/physiol Actions

F-box protein, is the critical component of conserved ubiquitin–protein ligase complex SCF (Skp1/Cdc53-Cullin1/F-box) and acts as a substrate recognition component of the ubiquitin ligase complex SCF (Skp-Cullin-F-box). It is expressed in human tissues including kidney, liver, brain and muscle tissues. It is associated with various critical biological processes such as in regulating the cell cycle, immune response, signaling cascades and developmental programs. The proteins have a bipartite structure and the core complex, whereas divergent protein-protein interaction motifs selectively bind their cognate substrates.

Physical form

Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Gennady P Ilyin et al.
Gene, 296(1-2), 11-20 (2002-10-18)
F-box proteins, a critical component of the evolutionary conserved ubiquitin-protein ligase complex SCF (Skp1/Cdc53-Cullin1/F-box), recruit substrates for ubiquitination and consequent degradation through their specific protein-protein interaction domains. Here, we report the identification of full-length cDNAs encoding three novel human F-box
K L Craig et al.
Progress in biophysics and molecular biology, 72(3), 299-328 (1999-12-03)
The ubiquitin system of intracellular protein degradation controls the abundance of many critical regulatory proteins. Specificity in the ubiquitin system is determined largely at the level of substrate recognition, a step that is mediated by E3 ubiquitin ligases. Analysis of
Margaret S Ho et al.
Journal of biomedical science, 13(2), 181-191 (2006-02-08)
The eukaryotic protein degradation pathway involves the ubiquitin (Ub) modification of substrates targeted for degradation by the 26S proteasome. The addition of Ub, a process called ubiquitination, is mediated by enzymes including the E3 Ub ligases which transfer the Ub
Laura Pontano Vaites et al.
Molecular and cellular biology, 31(22), 4513-4523 (2011-09-14)
Skp1-Cul1-F-box (SCF) E3 ubiquitin ligase complexes modulate the accumulation of key cell cycle regulatory proteins. Following the G(1)/S transition, SCF(Fbx4) targets cyclin D1 for proteasomal degradation, a critical event necessary for DNA replication fidelity. Deregulated cyclin D1 drives tumorigenesis, and

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