All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C189H282N48O56S5
CAS Number:
Molecular Weight:
4282.87
MDL number:
UNSPSC Code:
12352200
biological source
human
assay
≥95% (HPLC)
form
powder
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... EDN1(1906)
Amino Acid Sequence
Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser [Disulfide Bridges: 1-15; 3-11]
Biochem/physiol Actions
Precursor of endothelin 1; vasoconstrictor activity appears to be due to its conversion to endothelin 1 by endothelin converting enzyme in the tissue.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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M Burkhardt et al.
Journal of hypertension, 18(3), 273-279 (2000-03-22)
The aims of this study were to define and characterize the different mechanisms and sites of clearance of plasma endothelin-1 (ET-1) and big endothelin-1 (BigET-1) and evaluate possible effects of ETA versus combined ETA and ETB receptor blockade or endothelin
E Y Yap et al.
British journal of pharmacology, 129(1), 170-176 (2000-02-29)
All three endothelin precursor peptides, i.e. big endothelin-1 (big ET-1), big endothelin-2 (big ET-2) and big endothelin-3 (big ET-3), produced contractile responses in human isolated bronchi, demonstrating the presence of functional endothelin-converting enzyme (ECE) in this tissue. The maximal contractile
L Schilling et al.
Peptides, 21(1), 91-99 (2000-03-08)
The presence of functional endothelin converting enzyme (ECE) activity in basilar artery ring segments was investigated by measuring the contractile and relaxant effects of big endothelin (ET)-1. Under resting tension conditions cumulative application of big ET1-1 elicited a concentration-related contraction
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