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A7477

Sigma-Aldrich

Anti-ADAM-33, Catalytic Domain antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-A Disintegrin And Metalloproteinase-33

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About This Item

MDL number:
MFCD04974658
UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

species reactivity

human

concentration

~1 mg/mL

technique(s)

western blot: 1:1,000

UniProt accession no.

Q9BZ11

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... ADAM33(80332)

General description

A Disintegrin And Metalloproteinase-33 (ADAM-3) is a widely expressed protein that regulates cell-attachment by binding to integrins via cysteine-rich domains. ADAM-33 has also been associated with asthma susceptibility. Rabbit Anti-ADAM-33, Catalytic Domain antibody binds to the amino end of active human ADAM-33.
By immunoblotting against the reduced protein, the antibody identifies bands at 99 kDa (minor band), 58 kDa (major band), and cleaved products in cell lysates.

Immunogen

synthetic peptide corresponding to the amino end of active human ADAM-33.

Application

Rabbit Anti-ADAM-33, Catalytic Domain antibody can be used for westen blot applications at 1:1,000.

Physical form

Solution in phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificates of Analysis (COA)

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Paul Van Eerdewegh et al.
Nature, 418(6896), 426-430 (2002-07-12)
Asthma is a common respiratory disorder characterized by recurrent episodes of coughing, wheezing and breathlessness. Although environmental factors such as allergen exposure are risk factors in the development of asthma, both twin and family studies point to a strong genetic
Tsuyoshi Yoshinaka et al.
Gene, 282(1-2), 227-236 (2002-01-30)
The ADAM family of membrane-anchored proteins has a unique domain structure, with each containing a disintegrin and metalloprotease (ADAM) domain. We have isolated mouse and human cDNAs encoding a novel member of the ADAM family. The mouse and human predicted

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