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T9533

Sigma-Aldrich

Transforming Growth Factor-α from rat

powder, synthetic, γ-irradiated, suitable for cell culture

Synonym(s):

TGF-α

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About This Item

Empirical Formula (Hill Notation):
C244H367N71O71S6
CAS Number:
89899-53-6
Molecular Weight:
5623.35
MDL number:
MFCD00082077
UNSPSC Code:
12352200

biological source

synthetic

sterility

γ-irradiated

assay

~90% (HPLC)

form

powder

potency

0.02-2.0 ng/mL EC50 (using Balb/MK 1)

mol wt

5.5 kDa

composition

Peptide content, ~80%

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P01134

storage temp.

−20°C

Gene Information

rat ... Tgfa(24827) , Tgfa(24827)

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Amino Acid Sequence

Val-Val-Ser-His-Phe-Asn-Lys-Cys-Pro-Asp-Ser-His-Thr-Gln-Tyr-Cys-Phe-His-Gly-Thr-Cys-Arg-Phe-Leu-Val-Gln-Glu-Glu-Lys-Pro-Ala-Cys-Val-Cys-His-Ser-Gly-Tyr-Val-Gly-Val-Arg-Cys-Glu-His-Ala-Asp-Leu-Leu-Ala [Disulfide Bridges: 8-21; 16-32; 34-43]

Biochem/physiol Actions

Transforming growth factor-α (TGF-α), is a 5.5 kDa polypeptide containing 50 amino acids in its mature form. It was originally identified as an agent that reversibly confers a transformed phenotype upon normal non-neoplastic cells, such as normal rat kidney fibroblasts. This activity requires the presence of transforming growth factor-β (TGF-β), which potentiates the action of TGF-α via a separate receptor. TGF-α is synthesized by monocytes, keratinocytes and many tissues and tumors. Mice genetically engineered to be lacking TGF-α expression showed no abnormalities except for the detection of a "wavy" hair coat. TGF-α exerts its action through the EGF receptor.

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Storage Class

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flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

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