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T8947

Sigma-Aldrich

Tissue Inhibitor of Metalloproteinase-1

buffered aqueous solution, suitable for immunoblotting and ELISA

Synonym(s):

TIMP-1

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About This Item

MDL number:
MFCD00285922
UNSPSC Code:
12352202
NACRES:
NA.77

product name

Tissue Inhibitor of Metalloproteinase-1 human, recombinant, expressed in CHO cells, ~500 μg/mL protein, buffered aqueous solution

biological source

human

Quality Level

200

recombinant

expressed in CHO cells

form

buffered aqueous solution

mol wt

~29 kDa

concentration

~500 μg/mL protein

technique(s)

ELISA: suitable
immunoblotting: suitable

UniProt accession no.

P01033

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... TIMP1(7076)

Biochem/physiol Actions

Plays a key role in maintaining the balance between extracellular matrix (ECM) deposition and degradation, and can inhibit angiogenesis, a crucial step in tumor invasion. TIMP-1 has greater binding efficiency to MMP-9, MMP-1, and MMP-3 than the other MMPs.

Physical form

Supplied in 0.01 M sodium phosphate buffer pH 7.3, 0.15 M NaCl.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Gary J Litherland et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(8), 2175-2187 (2014-04-24)
To assess the role of glycogen synthase kinase 3 (GSK-3) as a regulator of cartilage destruction in human tissue and a murine model of osteoarthritis (OA). Surgical destabilization of the medial meniscus (DMM) was performed to induce experimental murine OA
Lena Vinther et al.
Protein expression and purification, 101, 157-164 (2014-07-08)
Tissue inhibitor of metalloproteinases-1 (TIMP-1) is an endogenous inhibitor of matrix metalloproteinases (MMPs) with reported tumor promoting, as well as inhibitory, effects. These paradoxical properties are presumably mediated by different biological functions, MMP-dependent as well as -independent, and probably related
Jiayin Peng et al.
Theriogenology, 84(9), 1636-1643 (2015-10-06)
Tissue inhibitors of metalloproteinases (TIMPs) are associated with several reproductive processes, such as mammalian follicular growth, ovulation, CL formation, and embryonic development. However, the expression and function of TIMPs in goat oviducts remain unclear. This work aimed to identify TIMP1
Chung-Han Tsai et al.
Nature communications, 5, 4804-4804 (2014-09-04)
Rab small GTPases are master regulators of membrane trafficking and guide vesicle targeting. Recent publications show that Rab-controlled trafficking pathways are altered during tumorigenesis. However, whether any of the Rabs plays a metastasis suppressor role is least explored. Here we
Tyler Duellman et al.
Traffic (Copenhagen, Denmark), 16(10), 1108-1126 (2015-07-25)
Matrix metalloproteinase-9 (MMP-9) is a secreted endoproteinase with a critical role in the regulation of the extracellular matrix and proteolytic activation of signaling molecules. Human (h)MMP-9 has two well-defined N-glycosylation sites at residues N38 and N120; however, their role has
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