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T7290

Sigma-Aldrich

Tyrphostin 25

≥98%

Synonym(s):

(3,4,5-Trihydroxybenzylidene)malononitrile

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About This Item

Empirical Formula (Hill Notation):
C10H6N2O3
CAS Number:
118409-58-8
Molecular Weight:
202.17
MDL number:
MFCD00133900
UNSPSC Code:
12352200
PubChem Substance ID:
24278753

assay

≥98%

potency

3 μM IC50

solubility

DMSO: >50 mg/mL, clear, yellow to orange

storage temp.

2-8°C

SMILES string

Oc1cc(cc(O)c1O)\C=C(\C#N)C#N

Gene Information

human ... EGFR(1956)

Application

Tyrphostin 25 has been used for studying its effect on transcriptional repression induced by the adenoviral oncoprotein, E1a, in HeLa cells[1]. Tyrphostin 25 has also been used to study the migration inhibition in IEC-6 cells[2].

Biochem/physiol Actions

EGFR tyrosine kinase inhibitor.
Tyrphostin 25 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain[3],[4].

Preparation Note

Tyrphostin 25 is soluble in DMSO at a concentration that is greater than 50 mg/ml and yields a clear, yellow to orange solution.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
082H0389
045H0179
025K0869
087K1109
043K1344

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Shahid Husain et al.
Biochemical and biophysical research communications, 297(5), 1102-1107 (2002-10-10)
In this study, we investigated the ability of prostaglandin F(2alpha) (PGF(2alpha)) to induce tyrosine phosphorylation of phospholipase C-gamma1 (PLC-gamma1) in cat iris sphincter smooth muscle (CISM) cells. PGF(2alpha)(1 microM) stimulated PLC-gamma1 tyrosine phosphorylation in a time- and dose-dependent manner with
J Lechner et al.
Renal failure, 23(3-4), 573-588 (2001-08-14)
The therapeutic administration of Interferon alpha2b (IFNalpha) is often accompanied by impaired renal function, i.e. reduced glomerular filtration rate and sometimes a so-called "capillary leak syndrome". To clarify the mechanism behind the renal dysfunction, confluent monolayers of LLC-PK1 cells were
Mahaboobi Jaleel et al.
Biochemistry, 43(25), 8247-8255 (2004-06-24)
Guanylyl cyclase C (GC-C), the receptor for guanylin, uroguanylin, and the heat-stable enterotoxin, regulates fluid balance in the intestine and extraintestinal tissues. The receptor has an extracellular domain, a single transmembrane spanning domain, and an intracellular domain that harbors a
Debjani Ghosh et al.
Bioscience reports, 22(3-4), 395-406 (2003-01-09)
In this study we show that protein tyrosine kinases (PTKs) and also protein tyrosine phosphatases are involved in the uptake of virulent and avirulent Leishmania donovani promastigotes by macrophage cells. Protein tyrosine kinase inhibitors such as genistein or tyrphostin 25
Yu-Jing Gao et al.
Cardiovascular research, 71(2), 363-373 (2006-06-08)
Recent studies have demonstrated that perivascular adipose tissue (PVAT) releases vascular relaxation factor(s). In this study, we examined if PVAT releases other vasoactive factors in response to perivascular nerve activation by electrical field stimulation (EFS). In Wistar-Kyoto rats, rings of
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