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T6661

Sigma-Aldrich

20,20,20-Trifluoroleukotriene E4

~50 μg/mL in methanol: water (7:3) containing 17 mM acetate buffer adjusted to pH 5.4 with NH4OH, ~98% (HPLC)

Synonym(s):

(5S,6R)-5-Hydroxy-6-(S-cysteinyl)-(7E,9E,11Z,14Z)-20,20,20-trifluoroeicosatetraenoic acid

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About This Item

Empirical Formula (Hill Notation):
C23H34F3NO5S
CAS Number:
131074-64-1
Molecular Weight:
493.58
MDL number:
MFCD00135267
UNSPSC Code:
12352211
PubChem Substance ID:
24900397

assay

~98% (HPLC)

concentration

~50 μg/mL in methanol: water (7:3) containing 17 mM acetate buffer adjusted to pH 5.4 with NH4OH

storage temp.

−20°C

SMILES string

NC(CSC(\C=C\C=C\C=C\C\C=C\CCCCC(F)(F)F)C(O)CCCC(O)=O)C(O)=O

InChI

1S/C23H34F3NO5S/c24-23(25,26)16-11-9-7-5-3-1-2-4-6-8-10-14-20(33-17-18(27)22(31)32)19(28)13-12-15-21(29)30/h2-6,8,10,14,18-20,28H,1,7,9,11-13,15-17,27H2,(H,29,30)(H,31,32)/b4-2+,5-3+,8-6+,14-10+

InChI key

KOJLKTXOQDHBBV-HBDLJKPYSA-N

Packaging

Packaged under Argon.

Certificates of Analysis (COA)

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G Jedlitschky et al.
Archives of biochemistry and biophysics, 282(2), 333-339 (1990-11-01)
omega-Oxidation with subsequent beta-oxidation from the omega-end is the major pathway for inactivation and degradation of leukotrienes. Oxidative degradation of leukotriene E4 (LTE4), N-acetyl-LTE4, and LTB4 was inhibited by the omega-trifluoro analogs of LTE4, omega-trifluoro-LTE4 (omega-F3-LTE4), and (1S,2R)-5-(3-[1-hydroxy-15,15,15-trifluoro-2-(2-1H- tetrazol-5-ylethyl-thio)pentadeca-3(E),5(Z)-dienyl+ ++]phenyl)-1H-tetrazole

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