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T6568

Sigma-Aldrich

Tyrphostin RG 13022

≥98%

Synonym(s):

2-(3,4′-Dimethoxyphenyl)-1-(3″-pyridinyl)acrylonitrile

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About This Item

Empirical Formula (Hill Notation):
C16H14N2O2
CAS Number:
136831-48-6
Molecular Weight:
266.29
MDL number:
MFCD00236444
UNSPSC Code:
12352200
PubChem Substance ID:
329826848
NACRES:
NA.77

assay

≥98%

form

solid

potency

IC50 (3 micromolar for inhibition of EGF-receptor.)

mp

114-115 °C

solubility

DMSO or ethanol: soluble

storage temp.

2-8°C

SMILES string

COc1ccc(cc1OC)\C=C(\C#N)c2cccnc2

InChI

1S/C16H14N2O2/c1-19-15-6-5-12(9-16(15)20-2)8-14(10-17)13-4-3-7-18-11-13/h3-9,11H,1-2H3

InChI key

DBGZNJVTHYFQJI-UHFFFAOYSA-N

Biochem/physiol Actions

Non-phenolic tyrphostin-class tyrosine kinase inhibitor.

Preparation Note

Tyrphostin RG 13022 is known to suppress EGF-induced cancer cell proliferation under in vitro conditions and can also inhibit the growth of tumors in nude mice.
Tyrphostin RG 13022 is soluble in DMSO and ethanol.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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T Yoneda et al.
Cancer research, 51(16), 4430-4435 (1991-08-15)
Many human tumors of epithelial origin contain cells overexpressing the epidermal growth factor (EGF) receptor, and there is convincing evidence that cancer cell growth is correlated with the loss of the normal regulation of the EGF receptor signal transduction pathway.
W Xian et al.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 6(11), 1447-1455 (1995-11-01)
The present study was designed to further investigate the role of the epidermal growth factor receptor (EGFr) in mouse skin tumor promotion by evaluating the status of the EGFr in tumor promoter-treated mouse epidermis and in mouse skin tumors. Female
K B Reddy et al.
Cancer research, 52(13), 3636-3641 (1992-07-01)
Human breast cancer cell proliferation is regulated by growth factors that bind to receptors with intrinsic tyrosine kinase (TK) activity, including the epidermal growth factor (EGF) receptor. To determine whether inhibition of receptor TK activity inhibits tumor growth, we studied
S Oomizu et al.
The Journal of endocrinology, 165(2), 493-501 (2000-05-16)
Oestrogen stimulates the proliferation of pituitary cells. The present study was designed to clarify the involvement of transforming growth factor-alpha (TGF-alpha) in the oestrogen-induced growth of mouse pituitary cells in vitro. Anterior pituitary cells obtained from ICR male mice were
S Takahashi et al.
Archives of physiology and biochemistry, 110(1-2), 34-41 (2002-04-06)
Estrogen stimulates the proliferation of pituitary cells, in particular mammotrophs. The present study was designed to clarify involvement of transforming growth factor alpha (TGF-alpha) in the estrogen-induced growth of mouse pituitary cells in vitro. Anterior pituitary cells obtained from ICR
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