T4693
Tyrphostin AG 537
≥98%
Synonym(s):
Bis-Tyrphostin
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About This Item
Empirical Formula (Hill Notation):
C23H20N4O6
Molecular Weight:
448.43
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
assay
≥98%
potency
0.4 μM IC50
solubility
DMSO: soluble
storage temp.
2-8°C
SMILES string
Oc1ccc(cc1O)\C=C(/C#N)C(=O)NCCCNC(=O)\C(=C\c2ccc(O)c(O)c2)C#N
Gene Information
human ... CDK2(1017) , EGFR(1956)
Biochem/physiol Actions
Tyrphostin AG 537 is a strong inhibitor of pro-PHBP (proenzyme form of plasma hyaluronan-binding protein) stimulation1.
EGF-R inhibitor
Preparation Note
Tyrphostin AG 537 is soluble in DMSO.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificates of Analysis (COA)
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Eisaku Yamamoto et al.
Bioscience, biotechnology, and biochemistry, 75(10), 2070-2072 (2011-10-08)
Plasma hyaluronan-binding protein (PHBP) is a serine protease the activation of which is implicated in inflammation. Previous investigations have suggested the presence of catechol-binding sites in its proenzyme form, pro-PHBP. Here we found that compounds with plural catechol groups conjugated
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