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T4138

Sigma-Aldrich

HT-2 Toxin

≥98% (HPLC)

Synonym(s):

15-Acetoxy-3α,4β-dihydroxy-8α-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene

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About This Item

Empirical Formula (Hill Notation):
C22H32O8
CAS Number:
26934-87-2
Molecular Weight:
424.48
MDL number:
MFCD00056784
UNSPSC Code:
12352205
PubChem Substance ID:
24900196
NACRES:
NA.25

Quality Level

200

assay

≥98% (HPLC)

availability

not available in USA

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

−20°C

SMILES string

[H][C@]12O[C@]3([H])[C@H](O)[C@@H](O)C(C)([C@@]1(COC(C)=O)C[C@H](OC(=O)CC(C)C)C(C)=C2)C34CO4

InChI

1S/C22H32O8/c1-11(2)6-16(24)29-14-8-21(9-27-13(4)23)15(7-12(14)3)30-19-17(25)18(26)20(21,5)22(19)10-28-22/h7,11,14-15,17-19,25-26H,6,8-10H2,1-5H3/t14-,15+,17+,18+,19+,20?,21+,22?/m0/s1

InChI key

PNKLMTPXERFKEN-CKRUGLOOSA-N

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Application

HT-2 toxin is a fusarium mycotoxin (secondary fungal metabolite toxic to human and animals) which may be used as a reference material in systems that detect mycotoxins. HT-2 toxin may be used in in vitro studies to understand its mechanisms of cytotoxicity.

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pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Benedikt Warth et al.
Rapid communications in mass spectrometry : RCM, 26(13), 1533-1540 (2012-05-29)
Mycotoxins regularly occur in food worldwide and pose serious health risks to consumers. Since individuals can be exposed to a variety of these toxic secondary metabolites of fungi at the same time, there is a demand for proper analytical methods
Maria Weidner et al.
Journal of agricultural and food chemistry, 60(22), 5676-5684 (2012-05-04)
The mycotoxin T-2 toxin, produced by various Fusarium species, is a widespread contaminant of grain and grain products. Knowledge about its toxicity and metabolism in the human body is crucial for any risk assessment as T-2 toxin can be detected
Linda Monaci et al.
Journal of chromatography. A, 1218(48), 8646-8654 (2011-10-29)
A sensitive and accurate method employing a single stage high resolution mass spectrometer equipped with a high-energy collision-dissociation cell (HCD) for the simultaneous determination of deoxynivalenol (DON), T-2 toxin (T-2) and HT-2 toxin (HT-2) in a processed bread model food
M De Boevre et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(5), 819-835 (2012-03-01)
An LC-MS/MS method was developed and validated for the simultaneous determination of deoxynivalenol, zearalenone, T-2-toxin, HT-2-toxin and metabolites, including 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, deoxynivalenol-3-glucoside, α-zearalenol, β-zearalenol, zearalenone-4-glucoside, α-zearalenol-4-glucoside, β-zearalenol-4-glucoside and zearalenone-4-sulfate in maize, wheat, oats, cornflakes and bread. Extraction was performed with
S De Baere et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(24), 2403-2415 (2011-07-20)
A sensitive and specific method for the quantitative determination of deoxynivalenol (DON), deepoxy-deoxynivalenol (DOM-1), T-2 toxin (T-2) and HT-2 toxin (HT-2) in animal body fluids (plasma and bile) using liquid chromatography combined with electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) is
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