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T0892

Interleukin-2 from rat

Name: Interleukin-2 from rat
Brand: SIGMA

from rat, suitable for cell culture

Synonym(s):

rIL-2, IL-2, T-Cell growth factor, IL-2

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About This Item

CAS Number:

95568-40-4

MDL number:

MFCD00131401

UNSPSC Code:

12352200

biological source

rat

form

solid

potency

0.2-2.5 units/mL

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P04351

Storage temp.

2-8°C

Gene Information

rat ... Il2(116562)

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Biochem/physiol Actions

Interleukin-2 is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lymphokine promotes long term growth of activated T cells and related cell types. Interleukin-2 plays a role in the activation and proliferation of NK cells, induces γ-interferon and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

Unit Definition

One unit is the amount required to induce half-maximal incorporation of ³H-thymidine into IL-2-dependent cytolytic T cell lymphocytes.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 1 mg bovine serum albumin

Preparation Note

Purified from a conditioned medium of a rat splenocyte culture stimulated by concanavalin A.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Interleukin-2-induced nitric oxide synthase and nuclear factor-kappaB activity in activated natural killer cells and the production of interferon-gamma.

M D Jyothi et al.

Scandinavian journal of immunology, 52(2), 148-155 (2000-08-10)

We have previously shown that inducible nitric oxide synthase (iNOS) was up-regulated in natural killer (NK) cells when AK-5 tumour cells were transplanted subcutaneously into syngeneic Wistar rats. This study was designed to investigate the role of interleukin (IL)-2 during

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