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S2320

Sigma-Aldrich

Anti-SFRS2 antibody produced in rabbit

affinity isolated antibody, PBS solution, contains 0.09% sodium azide as preservative

Synonym(s):

Anti-Splicing Factor Arginine/serine-rich 2

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About This Item

MDL number:
MFCD07370501
UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

PBS solution

mol wt

antigen 25.6 kDa

contains

0.09% sodium azide as preservative

species reactivity

human

technique(s)

immunohistochemistry: suitable
western blot: suitable

storage temp.

−20°C

Gene Information

human ... SFRS2(6427)
mouse ... Sfrs2(20382)
rat ... Sfrs2(494445)

Immunogen

synthetic peptide from the N-terminal region of SFRS2 conjugated to KLH.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Target description

SFRS2 (Splicing Factor Arginine/Serine-rich 2), alsoknown as PR264, SC35 (splicing component 35), and SRp30b, is a member of the SR protein family of splicing factors. SFRS2 regulates alternative splicing of pre-mRNA.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Matthew J Yousefzadeh et al.
EBioMedicine, 36, 18-28 (2018-10-04)
Senescence is a tumor suppressor mechanism activated in stressed cells to prevent replication of damaged DNA. Senescent cells have been demonstrated to play a causal role in driving aging and age-related diseases using genetic and pharmacologic approaches. We previously demonstrated
Rayna Rosati et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 24(24), 6509-6522 (2018-09-07)
Testosterone suppression in prostate cancer is limited by serious side effects and resistance via restoration of androgen receptor (AR) functionality. ELK1 is required for AR-dependent growth in various hormone-dependent and castration-resistant prostate cancer models. The amino-terminal domain of AR docks
Jana Kralovicova et al.
Nucleic acids research, 42(12), 8161-8173 (2014-06-20)
Splice-switching oligonucleotides (SSOs) have been widely used to inhibit exon usage but antisense strategies that promote removal of entire introns to increase splicing-mediated gene expression have not been developed. Here we show reduction of INS intron 1 retention by SSOs

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