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S2011

Sigma-Aldrich

[Met-OMe11]-Substance P

≥97% (HPLC)

Synonym(s):

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-OMe, Substance P methyl ester

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About This Item

Empirical Formula (Hill Notation):
C64H99N17O14S
CAS Number:
76260-78-1
Molecular Weight:
1362.64
MDL number:
MFCD00076782
UNSPSC Code:
12352200
PubChem Substance ID:
24899507

assay

≥97% (HPLC)

UniProt accession no.

P20366

storage temp.

−20°C

SMILES string

COC(=O)C(CCSC)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(Cc2ccccc2)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C3CCCN3C(=O)C(CCCCN)NC(=O)C4CCCN4C(=O)C(N)CCCNC(N)=N

Gene Information

human ... TAC1(6863)

Biochem/physiol Actions

Selective NK-1 receptor agonist

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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A M Yunker et al.
The American journal of physiology, 271(5 Pt 1), G904-G912 (1996-11-01)
Nitric oxide (NO) mediates neurogenic relaxations of gastrointestinal (GI) smooth muscle. NO synthase (NOS) inhibitors also alter neurogenic contractions, suggesting NO modulates excitatory neurotransmitter release. In circular muscle-myenteric plexus preparations, guanethidine and either scopolamine or CP-96,345, a neurokinin-1 (NK1) receptor
M Zhang et al.
Biopolymers, 33(12), 1901-1908 (1993-12-01)
High-resolution proton spectra at 500 MHz of two tachykinin peptides, substance P methyl ester (SPOMe) and [Nle10]-neurokinin A (4-10), have been obtained in dimethylsulfoxide (DMSO), and for SPOMe, also in 2,2,2-trifluoroethanol (TFE)/water mixtures. Complete chemical shift assignments for these peptides
D T Beattie et al.
British journal of pharmacology, 108(1), 146-149 (1993-01-01)
1. The effects of selective neurokinin agents on pial artery diameter, measured with an on-line image analyser, have been studied in anaesthetized guinea-pigs in order to characterize the neurokinin receptors present on pial arteries. 2. Perivascular injection of either substance
N D Fisher et al.
Neuroscience letters, 165(1-2), 84-88 (1994-01-03)
Using intracellular current clamp recording from motoneurones of the neonatal rat spinal cord in vitro, the action of tachykinin receptor agonists was investigated. Test drugs included the endogenously occurring neuropeptide substance P and synthetic compounds, such as substance P methylester
Y Tian et al.
Journal of neurochemistry, 67(3), 1191-1199 (1996-09-01)
Three chimeric receptors were constructed by exchanging exons between human neurokinin NK1 and NK3 receptor genes. The N-terminal sequences of these chimeric receptors are encoded by exon 1, exon 1-2, or exon 1-3 of the NK1 receptor gene, whereas the
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