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S0274

Sigma-Aldrich

[D-Arg1, D-Trp7,9, Leu11]-Substance P acetate salt

≥97% (HPLC)

Synonym(s):

Spantide I

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About This Item

Empirical Formula (Hill Notation):
C75H108N20O13 · xC2H4O2
CAS Number:
91224-37-2
Molecular Weight:
1497.79 (free base basis)
UNSPSC Code:
12352200

assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

CC(O)=O.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]6CCCN6C(=O)[C@H](CCCCN)NC(=O)[C@@H]7CCCN7C(=O)[C@H](N)CCCNC(N)=N)C(N)=O

Gene Information

human ... TACR1(6869)
mouse ... TACR1(21336)
rat ... TACR1(24807)

Amino Acid Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Trp-Phe-Trp-Leu-Leu-NH2

Biochem/physiol Actions

Potent NK-1 tachykinin receptor antagonist.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Zimei Zhou et al.
Investigative ophthalmology & visual science, 49(10), 4458-4467 (2008-06-21)
Apoptosis was examined after Pseudomonas aeruginosa corneal infection in C57BL/6 (B6, susceptible) and BALB/c (resistant) mice. TUNEL staining, real-time RT-PCR, polymorphonuclear neutrophils (PMNs) and macrophage (Mphi) depletion, and immunostaining were used. Intense TUNEL staining was seen in BALB/c versus B6
Sharon A McClellan et al.
Investigative ophthalmology & visual science, 49(4), 1502-1511 (2008-04-04)
Studies have shown that blocking substance P (SP) binding to neurokinin 1 receptor with spantide I prevents Pseudomonas aeruginosa-induced corneal perforation in susceptible C57BL/6 mice. This study tested the effect of SP injection on the resistance response (cornea heals) of
A C Broiz et al.
Neuroscience, 201, 134-145 (2011-11-30)
The dorsal periaqueductal gray (dPAG) is the main output structure for the defensive response to proximal aversive stimulation. Panic-like responses, such as freezing and escape behaviors, often result when this structure is electrically stimulated. Freezing also ensues after termination of
Radomir Radomirov et al.
Archives italiennes de biologie, 148(4), 377-388 (2011-02-11)
The evacuative motor responses of the anal canal and recto-anal reflexes during defecation were studied in an isolated rat recto-anal model preparation using (i) partitioned organ bath, (ii) electrical stimulation, (iii) balloon distension and (iv) morphological techniques. Electrical field stimulation
Qing Lin et al.
Molecular pain, 3, 30-30 (2007-10-27)
Acute cutaneous neurogenic inflammation initiated by activation of transient receptor potential vanilloid-1 (TRPV1) receptors following intradermal injection of capsaicin is mediated mainly by dorsal root reflexes (DRRs). Inflammatory neuropeptides are suggested to be released from primary afferent nociceptors participating in
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