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R5145

Sigma-Aldrich

Anti-Rsk1 antibody produced in rabbit

whole antiserum

Synonym(s):

Anti-p90rsk

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About This Item

MDL number:
MFCD00676462
UNSPSC Code:
12352203
NACRES:
NA.44

biological source

rabbit

conjugate

unconjugated

antibody form

whole antiserum

antibody product type

primary antibodies

clone

polyclonal

mol wt

antigen 80 kDa

contains

15 mM sodium azide

species reactivity

mouse, rat, human

technique(s)

microarray: suitable
western blot: 1:4,000 using mouse NIH 3T3 fibroblast cell lysate and rat brain extract

UniProt accession no.

Q15418

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RPS6KA1(6195)
mouse ... Rps6ka1(20111)
rat ... Rps6ka1(81771)

General description

Ribosomal S6 kinase 1(Rsk1) is a ubiquitously expressed, mitogen-activated protein that belongs to the serine/threonine protein kinases family. Several isoforms of Rsk have been cloned from mouse (Mo1 and Mo2) 4, 5 and human (HU1-3) source. All of these isoforms encode proteins with calculated molecular masses of about 70 kDa. Their apparent higher masses (90 kDa) may be due to hyperphosphorylation after activation.

Immunogen

Synthetic peptide corresponding to amino acids 707-723 of human Rsk1 coupled to KLH.

Application

Anti-Rsk1 antibody can be used in microarray and western blotting.

Biochem/physiol Actions

Ribosomal S6 kinase 1(Rsk1) is regulated via separate signal transduction pathways in response to mitogenic stimulation. It is an important component in nuclear signaling processes. Activation of p90rsk occurs rapidly through phosphorylation of Thr396 located in the kinase catalytic domain. Rsk can phosphorylate and regulate the activity of other molecules such as transcription factor c-fos.
Rsk1 has a pivotal role in facilitating MEK-MAP kinase cell survival signaling and supressing pro-apoptotic function of BAD by phosphorylating . Anti-Rsk1 antibody can be used for studying differential tissue expression of (p90rsk) and its intracellular localization in normal and neoplastic tissues. It can also be used to detect (p90rsk).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity
Roux PP, et al.
Molecular and Cellular Biology, 23(14), 4796-4804 (2003)
The RSK factors of activating the Ras/MAPK signaling cascade
Carriere A, et al.
Frontiers in Bioscience, 13(10), 4258-4275 (2008)
P70 S6 kinase mediates tau phosphorylation and synthesis
Pei JJ, et al.
Febs Letters, 580(1), 107-114 (2006)
Role of p90rsk in kidney and other diseases
Lin L, et al.
International Journal of Molecular Sciences, 20(4), 972-972 (2019)
A Shimamura et al.
Current biology : CB, 10(3), 127-135 (2000-02-19)
Growth factors activate an array of cell survival signaling pathways. Mitogen-activated protein (MAP) kinases transduce signals emanating from their upstream activators MAP kinase kinases (MEKs). The MEK-MAP kinase signaling cassette is a key regulatory pathway promoting cell survival. The downstream

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