R2278
Ro 48-8071 fumarate
≥98% (HPLC), solid
Synonym(s):
[4′-[6-(Allylmethylamino)hexyloxy]-4-bromo-2′-fluorobenzophenone fumarate (1:1)
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About This Item
Empirical Formula (Hill Notation):
C23H27NO2BrF · C4H4O4
CAS Number:
Molecular Weight:
564.44
MDL number:
UNSPSC Code:
12352200
assay
≥98% (HPLC)
form
solid
color
white
mp
90-92.7 °C
solubility
H2O: >5 mg/mL at ~60 °C
storage temp.
2-8°C
SMILES string
OC(=O)\C=C\C(O)=O.CN(CCCCCCOc1ccc(c(F)c1)C(=O)c2ccc(Br)cc2)CC=C
Biochem/physiol Actions
Orally active 2,3-oxidosqualene:lanosterol cyclase (OSC) inhibitor. OSC (EC 5.4.99.7) is a unique target for a cholesterol-lowering drug.
Orally active 2,3-oxidosqualene:lanosterol cyclase (OSC) inhibitor. OSC (EC 5.4.99.7) represents a unique target for a cholesterol-lowering drug. Partial inhibition of OSC should reduce synthesis of lanosterol and subsequent sterols, and also stimulate the production of epoxysterols that repress HMG-CoA reductase expression, generating a synergistic, self-limited negative regulatory loop.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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