The solubility specification was tested at 100 mg/ml in 1 M NaOH (refer to the specification sheet). Probenecid is soluble in chloroform, in dilute solutions of sodium hydroxide, then buffered to pH 7.4, and is nearly insoluble in water. It is also soluble in 1 M NaOH (50 mg/ml), producing a clear, colorless solution.
P8761
Probenecid
≥98% (NaOH, titration), powder, uricosuric agent
Synonym(s):
p-(Dipropylsulfamoyl)benzoic acid
Sign Into View Organizational & Contract Pricing
All Photos(1)
Select a Size
Change View
25 G
$114.00
100 G
$385.00
About This Item
Empirical Formula (Hill Notation):
C13H19NO4S
CAS Number:
Molecular Weight:
285.36
EC Number:
MDL number:
UNSPSC Code:
12161501
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Product Name
Probenecid,
assay
≥98% (NaOH, titration)
Quality Level
originator
Merck & Co., Inc., Kenilworth, NJ, U.S.
SMILES string
CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(O)=O
InChI
1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)
InChI key
DBABZHXKTCFAPX-UHFFFAOYSA-N
Gene Information
human ... SLC22A11(55867) , SLC22A6(9356) , SLC22A8(9376)
Looking for similar products? Visit Product Comparison Guide
Application
Probenecid has been used:
- as a component of phenol red free Hank′s buffer for Intracellular Ca2+-mobilization assay[1]
- as a component of calcium sensitive dye for calcium mobilization Studies[2]
- as a supplement in Hank′s balanced salt solution (HBSS) assay buffer[3]
Useful as an inhibitor of the organic anion transporter, MRP.
Biochem/physiol Actions
Probenecid is a uricosuric agent, which increases uric acid removal in the urine[4] and reduces urate reuptake.[5] It also reduces the renal tubular excretion of many other drugs and increases their plasma concentration. The inhibitory action of probenecid is mediated by organic anion transporters. It is found useful for the treatment of gout.[5] Probenecid is responsible for the rise in the levels of neurochemicals in the brain by preventing its movement from choroid plexus and parenchyma cells into plasma.[4]
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
Probenecid, a gout remedy, inhibits pannexin 1 channels
Harris D, et al.
American Journal of Physiology. Cell Physiology, 295, C761?C767-C761?C767 (2008)
Determining the potency and molecular mechanism of action of insurmountable antagonists.
Kenakin, T, et al.
Journal of Pharmacology and Experimental Therapeutics, 319, 710-723 (2014)
The
Drugs of Abuse: Neurological Reviews and Protocols, 109-109 (2003)
Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice
Tang X, et al.
Journal of Lipid Research, 55, 2389-2400 (2014)
Hiroshi Watanabe et al.
Kidney international, 83(4), 582-592 (2013-01-18)
The accumulation of p-cresyl sulfate (PCS), a uremic toxin, is associated with the mortality rate of chronic kidney disease patients; however, the biological functions and the mechanism of its action remain largely unknown. Here we determine whether PCS enhances the
Articles
Protein-based drug transporters are expressed in Sf9 cells. Understanding the specific mechanisms of tumor cell transporters is an essential aspect of chemotherapeutic drug design.
Discover Bioactive Small Molecules for ADME/Tox
-
What is the solubility and solution stability?
1 answer-
Helpful?
-
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
