P7956
Protein Kinase C from rat brain
>90% (SDS-PAGE), lyophilized powder
Synonym(s):
PKC
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About This Item
CAS Number:
MDL number:
UNSPSC Code:
12352200
assay
>90% (SDS-PAGE)
form
lyophilized powder
mol wt
82 kDa by SDS-PAGE
color
white
shipped in
dry ice
storage temp.
−20°C
Gene Information
rat ... Prkca(24680) , Prkcb(25023) , Prkcd(170538) , Prkce(29340) , Prkcg(24681) , Prkch(81749) , Prkci(84006) , Prkcz(25522) , Prkd1(85421)
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Biochem/physiol Actions
Ca2+-activated, phospholipid-dependent serine/threonine protein kinase.
Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and γ. Members of the second family are phospholipid-dependent but Ca2+-independent, and include PKCδ, ε, η, and θ. Members of the third family are not activated by either DAG or phorbol esters and include PKCξ, μ, and ι.
Phosphorylation appears to be an important mechanism of regulation of all PKCs. PKC plays a role in the regulation of cell transformation, growth, differentiation, ruffling, vesicle trafficking, apoptosis and gene expression.
Phosphorylation appears to be an important mechanism of regulation of all PKCs. PKC plays a role in the regulation of cell transformation, growth, differentiation, ruffling, vesicle trafficking, apoptosis and gene expression.
Other Notes
Mixture of isozymes.
Unit Definition
One unit will transfer 1 nmol of phosphate per min from ATP to histone H1 at pH 7.4 at 30 °C.
Physical form
Supplied as lyophilized white powder containing Tris buffer salts, EDTA, EGTA, DTT, Tween 20, sodium chloride, leupeptin, and sucrose as stabilizer.
Reconstitution
Reconstitute with 100 μl of dH2O.
inhibitor
Product No.
Description
Pricing
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Coleen M Atkins et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(22), 5193-5201 (2004-06-04)
Phosphorylation of cytoplasmic polyadenylation element binding protein (CPEB) regulates protein synthesis in hippocampal dendrites. CPEB binds the 3' untranslated region (UTR) of cytoplasmic mRNAs and, when phosphorylated, initiates mRNA polyadenylation and translation. We report that, of the protein kinases activated
Girdhar K Pandey et al.
Cell research, 17(5), 411-421 (2007-05-09)
Potassium is one of the major macro-nutrients essential for a number of cellular processes in plants. Low potassium level in the soil represents a limiting factor for crop production. Recent studies have identified potassium transporters that are involved in potassium
Mayuko Akaboshi et al.
Journal of molecular biology, 377(1), 246-257 (2008-02-02)
Calcium signals mediate a multitude of plant responses to external stimuli. Calcineurin B-like (CBL) proteins and their target kinases, CBL-interacting protein kinases (CIPKs), represent important relays in plant calcium signaling. CBL interacts with CIPK through a conserved motif (NAF/FISL motif)
Yahui Li et al.
Molecular human reproduction, 17(1), 42-56 (2010-08-24)
Members of the testis-specific serine/threonine kinases (Tssk) family may have a role in sperm differentiation in the testis and/or fertilization. To gain insight into the functional relevance of these kinases, their expression was examined both at the mRNA and protein
Nichole Link et al.
The Journal of cell biology, 178(4), 567-574 (2007-08-08)
We examined post-eclosion elimination of the Drosophila wing epithelium in vivo where collective "suicide waves" promote sudden, coordinated death of epithelial sheets without a final engulfment step. Like apoptosis in earlier developmental stages, this unique communal form of cell death
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