P5988
PA28 Activator from rabbit
≥95% (SDS-PAGE), buffered aqueous solution
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About This Item
MDL number:
UNSPSC Code:
12352202
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Quality Level
assay
≥95% (SDS-PAGE)
form
buffered aqueous solution
mol wt
170 kDa
shipped in
dry ice
storage temp.
−70°C
General description
Manufactured for Sigma by Boston Biochem., Inc.
Biochem/physiol Actions
Protein activator of the 20S proteasome. Enhances the 20S proteasome hydrolysis of peptide substrates, but not hydrolysis of ubiquitinated proteins.
Physical form
Solution in 50 mM Hepes, pH 7.6, 250 mM NaCl, 1 mM EDTA, and 1 mM DTT.
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificates of Analysis (COA)
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M Chu-Ping et al.
Biochimica et biophysica acta, 1119(3), 303-311 (1992-03-12)
An inhibitory protein for the 20S proteasome (also known as macropain, the multicatalytic proteinase complex and 20S proteinase) has been purified from bovine red blood cells. The inhibitor has an apparent molecular weight of 31,000 on SDS-PAGE and appears to
W Dubiel et al.
The Journal of biological chemistry, 267(31), 22369-22377 (1992-11-05)
We have identified and purified a protein complex from human red blood cells that activates the multicatalytic protease (MCP). The complex, which we call the regulator, sediments at 11 S and is composed of 30-kDa subunits. The regulator does not
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