Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

P5818

Sigma-Aldrich

Protein C, Activated, Fragment 390-404 human

~90% (HPLC)

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C91H130N22O23
CAS Number:
146340-20-7
Molecular Weight:
1900.14
MDL number:
MFCD00214128
UNSPSC Code:
12352202
PubChem Substance ID:
24898709

biological source

human

assay

~90% (HPLC)

form

powder

composition

Peptide content, ≥70%

UniProt accession no.

P04070

storage temp.

−20°C

SMILES string

CCC(C)C(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CC(O)=O)NC(=O)C(CC(C)C)NC(=O)C(Cc3ccc(O)cc3)NC(=O)C(CCCNC(N)=N)NC(=O)C(CO)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(NC(=O)C(Cc4ccc(O)cc4)NC(=O)C(NC(=O)CNC(=O)C(N)Cc5ccc(O)cc5)C(C)C)C(C)O)C(C)C)C(=O)NC(Cc6cnc[nH]6)C(O)=O

InChI

1S/C91H130N22O23/c1-10-49(8)75(88(133)108-69(90(135)136)39-55-42-96-45-100-55)112-84(129)67(38-54-41-98-61-17-12-11-16-59(54)61)105-82(127)68(40-72(120)121)106-80(125)64(34-46(2)3)103-81(126)65(36-52-22-28-57(117)29-23-52)104-78(123)63(19-15-33-97-91(94)95)101-85(130)70(44-114)109-87(132)74(48(6)7)111-79(124)62(18-13-14-32-92)102-89(134)76(50(9)115)113-83(128)66(37-53-24-30-58(118)31-25-53)107-86(131)73(47(4)5)110-71(119)43-99-77(122)60(93)35-51-20-26-56(116)27-21-51/h11-12,16-17,20-31,41-42,45-50,60,62-70,73-76,98,114-118H,10,13-15,18-19,32-40,43-44,92-93H2,1-9H3,(H,96,100)(H,99,122)(H,101,130)(H,102,134)(H,103,126)(H,104,123)(H,105,127)(H,106,125)(H,107,131)(H,108,133)(H,109,132)(H,110,119)(H,111,124)(H,112,129)(H,113,128)(H,120,121)(H,135,136)(H4,94,95,97)

InChI key

ZWIJLOHGIXGMAB-UHFFFAOYSA-N

Gene Information

human ... PROC(5624)

Amino Acid Sequence

Tyr-Gly-Val-Tyr-Thr-Lys-Val-Ser-Arg-Tyr-Leu-Asp-Trp-Ile-His

Biochem/physiol Actions

Fragment of activated protein C (APC) heavy chain that is essential for anticoagulant activity.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
089K0965
026K1313
105K1072
055K1199
035K1491

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

E Thorelli
Scandinavian journal of clinical and laboratory investigation. Supplementum, 229, 19-26 (1999-03-31)
Coagulation factor V is composed of domains A1-A2-B-A3-C1-C2 and is activated by thrombin through proteolytic cleavage at Arg 709, Arg 1018 and Arg 1545. Upon thrombin activation, the B-domain is released and the active factor Va is formed by the
R M Mesters et al.
Protein science : a publication of the Protein Society, 2(9), 1482-1489 (1993-09-01)
Activated protein C (APC) exerts its physiologic anticoagulant role by proteolytic inactivation of the blood coagulation cofactors Va and VIIIa. The synthetic peptide-(311-325) (KRNRTFVLNFIKIPV), derived from the heavy chain sequence of APC, potently inhibited APC anticoagulant activity in activated partial
R M Mesters et al.
The Journal of biological chemistry, 266(36), 24514-24519 (1991-12-25)
Activated protein C (APC) exerts its physiologic anticoagulant role by proteolytic inactivation of the blood coagulation cofactors Va and VIIIa. To identify the regions on the surface that mediate anticoagulant activity, 26 synthetic peptides were prepared representing 90% of the

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service