P4547
Prostaglandin A2 solution
10 mg/mL in methyl acetate, ~95%, synthetic
Synonym(s):
(5Z,13E,15S)-15-Hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid, PGA2
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About This Item
Empirical Formula (Hill Notation):
C20H30O4
CAS Number:
Molecular Weight:
334.45
Beilstein/REAXYS Number:
2221844
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
biological source
synthetic
assay
~95%
concentration
10 mg/mL in methyl acetate
storage temp.
−20°C
SMILES string
[H][C@]1(\C=C\[C@@H](O)CCCCC)C=CC(=O)[C@]1([H])C\C=C/CCCC(O)=O
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Biochem/physiol Actions
Blocks cell cycle at G2/M; induces apoptosis in tumor cells; inhibits viral replication; PPARγ agonist.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
target_organs
Central nervous system
supp_hazards
Storage Class
3 - Flammable liquids
wgk_germany
WGK 2
flash_point_f
15.8 °F
flash_point_c
-9 °C
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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Takumi Satoh et al.
The European journal of neuroscience, 17(11), 2249-2255 (2003-06-20)
Previously we found that some cyclopenteone prostaglandin derivatives (PGs), referred to as neurite outgrowth-promoting PGs (NEPPs), have dual biological activities of promoting neurite outgrowth and preventing neuronal death [Satoh et al. (2000) J. Neurochem., 75, 1092-1102; Satoh et al. (2001)
K Ohno et al.
Chemico-biological interactions, 78(1), 67-75 (1991-01-01)
Prostaglandin A2 (PGA2) stimulates the biosynthesis of gamma-glutamylcysteine synthetase and elevates glutathione (GSH) contents in cultured mammalian cells. To clarify the importance of gamma-glutamylcysteine synthetase induction in the defence of endothelial cells against oxidative stress, the effect of PGA2 on
Emmanuel Gaquerel et al.
Biochimica et biophysica acta, 1771(5), 565-575 (2007-04-13)
Signaling cascades involving oxygenated derivatives (oxylipins) of polyunsaturated fatty acids (PUFAs) are known to operate in response to external stimuli. The marine red alga Chondrus crispus uses both oxygenated derivatives of C18 (octadecanoids) and C20 (eicosanoids) PUFAs as developmental or
Fabiano E Xavier et al.
Clinical science (London, England : 1979), 119(7), 283-292 (2010-05-13)
Our present study examines, in mesenteric resistance arteries, possible vasodilation alterations, and the role of NO and COX (cyclo-oxygenase) derivatives, in cirrhosis. The vasodilator response to acetylcholine was analysed in segments from control and cirrhotic rats. The effects of the
Lakshminarasimhan Pavithra et al.
Nucleic acids research, 35(18), 6004-6016 (2007-08-30)
Prostaglandins are anticancer agents known to inhibit tumor cell proliferation both in vitro and in vivo by affecting the mRNA stability. Here we report that a MAR-binding protein SMAR1 is a target of Prostaglandin A2 (PGA2) induced growth arrest. We
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